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FLASH GENE
Symbol MLST8 contributors: mct - updated : 09-01-2019
HGNC name MTOR associated protein, LST8 homolog
HGNC id 24825
Location 16p13.3      Physical location : 2.255.449 - 2.259.417
Synonym name
  • TORC subunit LST8
  • gable
  • mammalian lethal with SEC13 protein 8
  • protein GbetaL
  • Synonym symbol(s) GBL, GbetaL, LST8, POP3, WAT1, MGC111011
    DNA
    TYPE functioning gene
    STRUCTURE 4.83 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2048 - 260 - 2003 12718876
    9 - 1979 - 332 - 2003 12718876
    9 - 1961 - 326 - 2003 12718876
    9 - 1958 - 325 - 2003 12718876
    8 - 2018 - 260 - 2003 12718876
    9 - 1931 - 326 - 2003 12718876
    9 - 1776 - 326 - 2003 12718876
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • MLST8 plays distinct roles in normal and cancer cells, depending upon its expression level
  • is an indispensable protein subunit of mammalian target of rapamycin (MTOR) signaling pathway that interacts with the kinase domain of mTOR protein, thereby stabilizing its active site
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLST8 bridges between CAD and MTOR, and plays a role in the signaling mechanism where CAD is regulated in the MTOR pathway through the association with MLST8
  • MLST8 upregulation may contribute to tumor progression by constitutively activating both the MTOR and CRTC2 pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several human colon and prostate cancer cell lines and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    targeting MLST8 protein would be a therapeutic approach against tumor progression in colon cancers
    cancerreproductiveprostate
    targeting MLST8 protein would be a therapeutic approach against tumor progression in prostate cancers
    ANIMAL & CELL MODELS