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FLASH GENE
Symbol MLLT6 contributors: - updated : 03-01-2006
HGNC name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
HGNC id 7138
Location 17q21      Physical location : 36.861.872 - 36.886.055
Synonym name AF-17 protein
Synonym symbol(s) AF17
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Cardiovascularheart   highly
Digestiveliver   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two zinc finger (leukemia-associated-protein, LAP) basic leucine zipper (bZIP) dimerization domains
  • one cysteine rich domain
  • PHD zinc finger and FYVE domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the beta catenin T cell factor/lymphoid enhancer factor signaling pathway and to function as growth promoting oncogenic protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with HRX (MLL),in acute lymphoblastic leukemia and monoblastic leukemia with granulocytic sarcomas with translocation t(11;17)(q23;q21), maybe the same as TCF11
    tumoral   amplification    
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS