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FLASH GENE
Symbol MLLT11 contributors: mct - updated : 03-10-2012
HGNC name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
HGNC id 16997
Location 1q21.3      Physical location : 151.032.150 - 151.040.972
Synonym name
  • ALL1-fused gene from chromosome 1q
  • protein AF1q
  • Synonym symbol(s) AF1Q, RP11-316M1.10
    DNA
    TYPE functioning gene
    STRUCTURE 8.82 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2180 - 90 - 2008 17929166
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage highly in neural stem/progenitor cells
    cell lines hematopoietic cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • cooperates with the NOTCH signaling pathway to foster the emergence of BM prothymocytes and drive subsequent intrathymic specification toward the T-cell lineage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT11 up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with HRX (MLL) in infantile acute myelomonocytic leukemia, with translocation t(1;11)(q21;q23)
    tumoral     --over  
    in high-risk myelodysplastic syndrome
    tumoral     --over  
    is a poor prognostic marker for adult patients with normal cytogenetics -acute myeloid leukemia
    tumoral     --over  
    leads to a more progression in breast cancer, at least in part, through regulating the integrin alpha3, ETS1, MMP2, TRIM25 and YWHAD expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS