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FLASH GENE

Symbol

MLLT10

contributors: mct/ - updated : 08-09-2012

HGNC name	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
HGNC id	16063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p12.31      Physical location : 21.823.101 - 22.032.555
Synonym name	ALL fused from chromosome 10
	AF-10 protein
Synonym symbol(s)	AF10, DKFZp686E10210, MGC75086

DNA

TYPE	functioning gene
STRUCTURE	209.45 kb     24 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	pter - D10S548 - D10S203 /D10S595 - MLLT10 - PCGF4 - D10S211 - D10S550 - cen
Authors	Dreyling (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001195626 - - 4864 NP_001182555 - 1068 - 1998 9737689 also called variant 3 NM_001195627 - - 1254 NP_001182556 - 126 - 1998 9737689 also called variant 4 NM_001195628 - - 1122 NP_001182557 - 179 - 1998 9737689 also called variant 6 NM_001195630 - - 1148 NP_001182559 - 179 - 1998 9737689 also called variant 5 NM_004641 24 - 5137 NP_004632 - 1027 - 1998 9737689 also called variant 1

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two PHD zinc finger (leukemia-associated-protein, LAP)
	C terminal basic leucine zipper domains

HOMOLOGY

interspecies

homolog to murine mllt10

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	truncated AF-10 has potentially cellular function in normal and malignant cells
	PICALM/MLLT10 might interfere with normal Ikaros (IKZF1)function, and thereby block lymphoid differentiation in PICALM/MLLT10 positive leukemias
	MLLT10/AF10 and DOT1L are essential activators to a large extent dedicated to Wnt target gene regulation
	participates in several chromosomal rearrangements that result in various leukemias (

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

DOT1L

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with MLL in acute lymphoblastic leukemia in translocation t(10;11)(p12;q23), and in acute megakaryoblastic leukemia tumoral fusion       with PICALM in T-ALL, AML, in translocation t(10;11) (p13;q14) tumoral fusion inversion     with CLP1 and MLL in monoblastic leukemia (Inv.Ins[10,11] [p12,q23-q12])

Susceptibility

to meningioma

Variant & Polymorphism SNP	rs11012732 influences meningioma risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS