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FLASH GENE
Symbol MLLT10 contributors: mct/ - updated : 08-09-2012
HGNC name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
HGNC id 16063
Location 10p12.31      Physical location : 21.823.101 - 22.032.555
Synonym name
  • ALL fused from chromosome 10
  • AF-10 protein
  • Synonym symbol(s) AF10, DKFZp686E10210, MGC75086
    DNA
    TYPE functioning gene
    STRUCTURE 209.45 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D10S548 - D10S203 /D10S595 - MLLT10 - PCGF4 - D10S211 - D10S550 - cen
    Authors Dreyling (96)
    Physical map
    DNMT2 10p15.1 DNA (cytosine-5-)-methyltransferase 2 VIM 10p13 vimentin ST8SIA-VI 10p13 alpha 2,8-sialyltransferase PTPLA 10p14-p13 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a STAM 10p14-p13 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 LOC340843 10p13 similar to protein of unknown function LOC340893 10p13 similar to protein of unknown function MRC1 10p13 mannose receptor, C type 1 SLC39A12 10p13 solute carrier family 39 (zinc transporter), member 12 CACNB2 10p12 calcium channel, voltage-dependent, beta 2 subunit NOPD1 10p13 nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 ARL8 10p13 ADP-ribosylation factor-like 8 LOC389942 10 similar to Programmed cell death protein 8, mitochondrial precursor (Apoptosis-inducing factor) LOC387635 10 similar to ubiquitin-conjugating enzyme E2 variant 1 isoform a; DNA-binding protein LOC340895 10p12.33 similar to apical early endosomal glycoprotein precursor LOC387636 10 LOC387636 PLXDC2 10p12.33 plexin domain containing 2 LOC220998 10p12.33 similar to Protein C21orf59 NEBL 10p12 similar to Protein C21orf59 LOC387637 10 similar to eukaryotic initiation factor 4B LOC387638 10 LOC387638 LOC387639 10 LOC387639 LOC219689 10p12.33 similar to putative RNA methyltransferase LOC387640 10 similar to RIKEN cDNA E130012A19 MLLT10 10p12 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 DNAJC1 10p12.31 DnaJ (Hsp40) homolog, subfamily C, member 1 LOC340900 10p12.32 similar to Hypothetical protein FLJ10213 LOC338098 10p12 proteasome activator subunit 2 pseudogene LOC389943 10 similar to ribosomal protein L31 BMI1 10p13 B lymphoma MO-MLV insertion region (mouse) C10orf8 10pter-q22.1 chromosome 10 open reading frame 8 SPAG6 10p12-p11.2 sperm associated antigen 6 PIP5K2A 10p11.23 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha FLJ32827 PILB 10p12 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha LOC143371 10p12.31 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene PTF1A 10p12.31 pancreas specific transcription factor, 1a LOC387642 10 similar to RIKEN cDNA 4921522E24 MGC46732 LOC220213 10p12.31 hypothetical protein LOC220213 DKFZP761L0424 ARHGAP21 10p12.31 Rho GTPase activating protein 21 PRTFDC1 10p12.31 phosphoribosyl transferase domain containing 1 MGC26778 FLJ22002 10p12.31 hypothetical protein FLJ22002 GPR158 10p12.31 G protein-coupled receptor 158 MYO3A 10p11.1 myosin IIIA GAD2 10p11.23 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4864 - 1068 - 1998 9737689
    also called variant 3
    - - 1254 - 126 - 1998 9737689
    also called variant 4
    - - 1122 - 179 - 1998 9737689
    also called variant 6
    - - 1148 - 179 - 1998 9737689
    also called variant 5
    24 - 5137 - 1027 - 1998 9737689
    also called variant 1
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two PHD zinc finger (leukemia-associated-protein, LAP)
  • C terminal basic leucine zipper domains
  • HOMOLOGY
    interspecies homolog to murine mllt10
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • truncated AF-10 has potentially cellular function in normal and malignant cells
  • PICALM/MLLT10 might interfere with normal Ikaros (IKZF1)function, and thereby block lymphoid differentiation in PICALM/MLLT10 positive leukemias
  • MLLT10/AF10 and DOT1L are essential activators to a large extent dedicated to Wnt target gene regulation
  • participates in several chromosomal rearrangements that result in various leukemias (
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DOT1L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with MLL in acute lymphoblastic leukemia in translocation t(10;11)(p12;q23), and in acute megakaryoblastic leukemia
    tumoral fusion      
    with PICALM in T-ALL, AML, in translocation t(10;11) (p13;q14)
    tumoral fusion inversion    
    with CLP1 and MLL in monoblastic leukemia (Inv.Ins[10,11] [p12,q23-q12])
    Susceptibility to meningioma
    Variant & Polymorphism SNP
  • rs11012732 influences meningioma risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS