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FLASH GENE
Symbol MLLT1 contributors: mct/npt - updated : 26-03-2010
HGNC name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
HGNC id 7134
Location 19p13.3      Physical location : 6.210.392 - 6.279.959
Synonym name
  • leukemia translocation gene on chromosome 19
  • eleven nineteen leukemia
  • MLLT1/MLL fusion
  • ENL/MLL fusion
  • YEATS domain-containing protein 1
  • Synonym symbol(s) ENL, LTG19, YEATS1
    DNA
    TYPE functioning gene
    STRUCTURE 69.57 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PLAC2 19p13.3 placenta-specific 2 LOC148064 19p13.3 similar to small nuclear ribonucleoprotein E SAFB2 19p13.3 scaffold attachment factor B2 SAFB 19p13.3-p13.2 scaffold attachment factor B LOC125988 19p13.3 hypothetical gene LOC125988 SCDR10 19p13.3 short-chain dehydrogenase/reductase 10 RPL36 19p13.3-p13.2 ribosomal protein L36 PRSS15 19p13.2 protease, serine, 15 MGC39581 19p13.3 hypothetical protein MGC39581 MGC24975 19p13.3 hypothetical protein MGC24975 LOC56931 19p13.3 hypothetical protein from EUROIMAGE 1967720 FUT6 19p13.3 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) NRTN 19p13.3 neurturin FUT3 19p13.3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) FUT5 19p13.3 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) NDUFA11 19p13.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa CAPS 19p13.3 calcyphosine RANBP3 19p13.3 RAN binding protein 3 RFX2 19p13.3 regulatory factor X, 2 (influences HLA class II expression) BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7 TNFSF14 19p13.3 tumor necrosis factor (ligand) superfamily, member 14 C3 19p13.3 complement component 3 GPR108 19p13.3 G protein-coupled receptor 108 TRIP10 19p13.3 thyroid hormone receptor interactor 10 SH2D3A 19p13.3 SH2 domain containing 3A VAV1 19p13.3 vav 1 oncogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4530 - 559 - Meyer (2007)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland  
     female systemovary   
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine/proline rich nuclear protein
  • C-terminal domain from MLLT1 is required for optimal interaction with DOT1L
  • HOMOLOGY
    intraspecies homolog to mllt3
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating transcription in lymphoid and myeloid cells
  • involved in essential developmental processes and suggest that expression patterns of MLL fusion partners may influence the lineage of MLL-associated leukemias (Doty 2002)
  • may have a function in histone modification and transcriptional elongation (Mueller 2007)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription activating factor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to c-Abl interactor protein (SSH3BP1) with CBX8
  • the entire C-terminal domain from MLLT1 is required for optimal interaction with DOT1L, which is consistent with the reports that helical segments are essential for the transformation potential of MLL-MLLT1 fusion protein
  • direct interaction between MLLT3/MLLT1 and DOT1L and for optimal interaction an intact C-terminal domain in MLL fusion proteins is critical
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation (t(11;19)(q23;p13.3) are associated with de novo acute leukemia as well as therapy-related acute leukemia (Lee 2010)
    tumoral   translocation    
    three-way translocation of t(2;19;11)(p12;p13.3;q23) in a patient with acute lymphoblastic leukemia (ALL)(Lee 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    disruption of interaction between DOT1L and MLLT3/MLLT1 is a promising therapeutic strategy with potentially fewer adverse effects than enzymatic inhibition of DOT1L for KMT2A fusion protein-associated leukemia
    ANIMAL & CELL MODELS