Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MLKL contributors: mct - updated : 23-12-2014
HGNC name mixed lineage kinase domain-like
HGNC id 26617
Location 16q23.1      Physical location : 74.705.752 - 74.734.789
DNA
TYPE functioning gene
STRUCTURE 29.04 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1898 - 263 - 2012 22265413
11 - 2522 - 471 - 2012 22265413
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal coiled-coil domain
  • a four-helical bundle tethered to the pseudokinase domain, which contains an unusual pseudoactive site
  • C-terminal kinase-like domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • locates to the cell plasma membrane during TNF-induced necroptosis
  • basic FUNCTION
  • is a key mediator of necrosis signaling downstream of the kinase RIPK3
  • is a key RIP3 downstream component of TNF-induced necrotic cell death
  • essential checkpoint in the programmed necrosis or "necroptosis" cell death pathway
  • crucial mechanism of MLKL-mediated TNF-induced necroptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pseudokinase MLKL functions as a substrate of RIPK3 to mediate downstream signaling
  • key RIPK3 downstream component of tumour necrosis factor (TNF)-induced necroptosis
  • TRPM7 (transient receptor potential melastatin related 7) is a MLKL downstream target for the mediation of Ca2+ influx and TNF-induced necroptosis
  • RHIM motif of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development
  • cell & other
    REGULATION
    Phosphorylated by RIPK3 and is recruited to the necrosome through its interaction with RIPK3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MLKL expression may serve as a potential prognostic marker in patients with ovarian cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • Mlkl-deficient mice were viable and displayed no hematopoietic anomalies or other obvious pathology, but cells derived from these animals were resistant to TNF-induced necroptosis unless MLKL expression was restored