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FLASH GENE
Symbol MLF1 contributors: mct/npt - updated : 16-01-2009
HGNC name myeloid leukemia factor 1
HGNC id 7125
Location 3q25.32      Physical location : 158.288.952 - 158.324.248
Synonym name
  • myeloid leukemia factor 1 variant 1
  • myeloid leukemia factor 1 variant 2
  • myeloid leukemia factor 1 variant 3
  • myelodysplasia-myeloid leukemia factor 1
  • DNA
    TYPE functioning gene
    STRUCTURE 34.20 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map D3S1605 - MLF1 - D3S2404 - D3S3692
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2208 30.5 268 - -
    - splicing 2325 27.5 243 - -
  • having an additional segment and an exon in the 5' UTR, which results in a downstream AUG start codon compared to variant 1
  • - splicing 2252 27.5 243 - -
  • having an additional segment in the 5' UTR, which results in a downstream AUG start codon compared to variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear targeting signal
  • a classic RSXSXP sequence for 14-3-3 binding and is associated with YWHAZ via this phosphorylated motif
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to dog MLF1 (79 pc)
    homolog to chimpanzee MLF1 (98.5 pc)
    homolog to cow MLF1 (81.7 pc)
    homolog to rattus Mlf1 (79 pc)
    homolog to murine MLf1 (81.2 pc)
    Homologene
    FAMILY
  • MLF family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • nucleolar when fused with NPM
  • retained in the nucleus by binding to HNRPUL2
  • retained in the cytoplasm by binding to YWHAZ
  • basic FUNCTION
  • involved in normal hemopoietic differentiation as well as in erythroid/myeloid lineage switching
  • interfering with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels
  • suppressing RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest (being a critical regulator of p53)
  • affecting the expression of a number of genes so may function as a transcription factor in the nucleus
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • cell cycle arrest
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with ADAM10 and YWHAZ (influencing its subcellular localization and biological function)
  • interacting with HNRPUL2
  • interacting with MLF1IP
  • interacting with NRBP1/MADM
  • binding to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53
  • cell & other
    REGULATION
    Other Phosphorylated MLF1 (then binding to YWHAZ and is retained in the cytoplasm)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(3;5)(q25.1;q34) with NPM1/NPM in myelodysplastic syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS