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FLASH GENE
Symbol MLEC contributors: mct - updated : 13-03-2019
HGNC name malectin
HGNC id 28973
Location 12q24.31      Physical location : 121.124.948 - 121.139.667
Synonym name
  • hypothetical protein KIAA0152
  • hypothetical protein LOC9761
  • Synonym symbol(s) KIAA0152
    DNA
    TYPE functioning gene
    STRUCTURE 14.74 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 6148 - 217 - 2008 18524852
    5 - 6100 - 209 - 2008 18524852
    5 - 6367 32 292 - 2008 18524852
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Respiratorylung    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans f44E2.4.
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • endoplasmic reticulum-resident lectin
  • endogenous malectin mainly localizes in the ER, which is disrupted upon suppression of ribophorin I, leading to its movement from ER to Golgi
  • basic FUNCTION
  • possible role of malectin in the N-glycosylation pathway
  • conserved, endoplasmic reticulum (ER)-resident lectin that recognizes high mannose oligosaccharides displaying terminal glucose residues
  • ER stress-induced protein that selectively associates with glycopolypeptides without affecting their entry and their retention in the Calnexin chaperone system
  • participates in a backup glycoprotein quality control pathway in the mammalian ER
  • possible role for MLEC in the quality control of glycoproteins via formation of a complex with RPN1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with ribophorin I for selective retention of misfolded glycoproteins inside the cell
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RPN1 may play a central role in the selective association between MLEC and misfolded glycoproteins
  • association of malectin with ribophorin I is required to capture misfolded glycoproteins and direct them to the degradation pathway
  • subcellular localization of malectin is accurately regulated by the expression level of RPN1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to cerebral palsy (CP)
    Variant & Polymorphism SNP
  • significant associations between the risk of CP and rs10431386
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS