basic FUNCTION
| may be involved in transcription regulation |
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may have a role in embryonic development |
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atypical homeodomain-containing protein with transcriptional repressor activity (Liu 2010) |
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important regulator of vertebrate development (Anderson 2006) |
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important regulator of tendon development (Liu 2010) |
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plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells (Ito 2010) |
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is a potent transcriptional repressor expressed in the embryonic precursors of skeletal muscle, cartilage, and bone |
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role for MKX in promoting slow fiber type specification during skeletal muscle differentiation |
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is capable of regulating its own promoter and this regulation is dependent upon amino acids within the homeodomain |
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role for MKX in the regulation of fiber type specificity during skeletal muscle differentiation |
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appears necessary to maintain the tissue-specific cellular differentiation status and ECM production in adult tendons and ligaments |
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is a key factor for tenogenic differentiation of MSCs (mesenchymal stem cells) |
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is an important regulator of tenogenic differentiation |
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roles of MKX in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFB1 pathway |
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tendon-specific transcription factor, is essential in mechanoresponsive tenogenesis through regulation of its downstream extracellular matrix (ECM) genes such as type I collagens and proteoglycans such as fibromodulin |
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key transcription factor that regulates annulus fibrosus (AF) of intervertebral discs development, maintenance and regeneration |
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tendon-specific transcription factor, regulating periodontal ligament (PDL) homeostasis by preventing its degeneration |
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MKX prevents PDL degeneration by regulating osteogenesis |