Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MKRN3 contributors: - updated : 24-12-2005
HGNC name markorin 3, ring finger protein, 3
HGNC id 7114
Location 15q11-q13      Physical location : 23.810.453 - 23.813.164
Synonym symbol(s) D15S9, HZF13, ZNF127, ZFP127
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping
text
  • associated with a 5'differentiated methylated region (DMR)
  • overlapping antisense transcript ZNF127A5
  • STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - BCL8 - D15S912 - D15S18 - D15S1035 ,D15S541 ,D15S542 - D15S16 - D15S17 - D15S543 - D15S59 - MKRN3 /ZNF127AS - D15S11 - D15S646 - D15S817 - D15S1524 - D15S1525 - D15S675 - qter
    Authors Christian (98), Jong (99)
    Physical map
    LOC390538 15 similar to Olfactory receptor 4M2 LOC390539 15 similar to seven transmembrane helix receptor LOC388076 15 similar to 40S ribosomal protein S8 LOC388077 15 similar to immunoglobulin heavy chain variable region LOC390540 15 similar to salivary proline-rich protein LOC388078 15 similar to FLJ27099 protein LOC388079 15 similar to ZCCHC2 protein LOC390541 15 similar to arginine-glutamic acid dipeptide (RE) repeats; atrophin 1-like; arginine glutamic acid dipeptide RE repeats LOC390542 15 similar to CDNA sequence BC005632 LOC390543 15 similar to ATP-binding cassette, sub-family B, member 10, mitochondrial precursor (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2) LOC388080 15 similar to hypothetical protein LOC283767 15q11.2 hypothetical gene supported by AK093450 LOC390544 15 similar to engulfment and cell motility 2; ced-12 homolog 2; PH domain protein CED12A TUBGCP5 15q11.1 tubulin, gamma complex associated protein 5 CYFIP1 15q11 cytoplasmic FMR1 interacting protein 1 NIPA2 15q11.2 non-imprinted in Prader-Willi/Angelman syndrome 2 SPG6 15q11-q13 spastic paraplegia 6 (autosomal dominant) LOC339003 15q11.2 similar to HP95 LOC388081 15 LOC388081 LOC339005 15q11.2 hypothetical protein LOC339005 FLJ35785 15q11.2 hypothetical protein FLJ35785 LOC388082 15 hypothetical gene supported by AB002391 LOC390545 15 similar to hypothetical protein FLJ36144 LOC390546 15 similar to golgin-67 isoform c LOC388083 15 similar to hypothetical protein FLJ31951 LOC390547 15 similar to neuronal nonacetlycholine binding subunit LOC390548 15 similar to hypothetical protein FLJ36144 LOC388084 15 similar to FLJ40113 protein LOC388085 15 similar to Golgi autoantigen, golgin subfamily a, 2; golgin-95; Golgi matrix protein GM130; SY11 protein LOC390549 15 similar to hect domain and RLD 2 FLJ36144 15q11.2 hypothetical protein FLJ36144 MKRN3 15q11-q12 makorin, ring finger protein, 3 MAGEL2 15q11.2-q12 MAGE-like 2 NDN 15q11.2-q12 necdin homolog (mouse) C15orf2 15q11-q13 chromosome 15 open reading frame 2 SNRPN 15q11.2-q12 small nuclear ribonucleoprotein polypeptide N SNURF 15q12 SNRPN upstream reading frame
    regionally located in the Prader-Willi critical region
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING maternally
    text ubiquitous from the paternal allele, maternally imprinted
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a distinctive array of zinc-finger motifs including two to four zinc fingers
  • a higly conserved RING-H2 zinc finger motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • mediating ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to a nuclear matrix attachment (MAR) sequence
    RNA binding
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    mapped within the commonly deleted PWS/AS region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS