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FLASH GENE
Symbol MKRN3 contributors: - updated : 24-12-2005
HGNC name markorin 3, ring finger protein, 3
HGNC id 7114
Location 15q11-q13      Physical location : 23.810.453 - 23.813.164
Synonym symbol(s) D15S9, HZF13, ZNF127, ZFP127
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping
text
  • associated with a 5'differentiated methylated region (DMR)
  • overlapping antisense transcript ZNF127A5
    • STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - BCL8 - D15S912 - D15S18 - D15S1035 ,D15S541 ,D15S542 - D15S16 - D15S17 - D15S543 - D15S59 - MKRN3 /ZNF127AS - D15S11 - D15S646 - D15S817 - D15S1524 - D15S1525 - D15S675 - qter
    Authors Christian (98), Jong (99)
    regionally located in the Prader-Willi critical region
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING maternally
    text ubiquitous from the paternal allele, maternally imprinted
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a distinctive array of zinc-finger motifs including two to four zinc fingers
  • a higly conserved RING-H2 zinc finger motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • mediating ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
    • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to a nuclear matrix attachment (MAR) sequence
    RNA binding
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    mapped within the commonly deleted PWS/AS region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS