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FLASH GENE
Symbol MKRN1 contributors: mct - updated : 18-01-2014
HGNC name makorin ring finger protein 1
HGNC id 7112
Location 7q34      Physical location : 140.152.839 - 140.179.369
Synonym name RING finger protein 61
Synonym symbol(s) RNF61, FLJ21334
DNA
TYPE functioning gene
STRUCTURE 26.53 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3158 53 482 - 2006 16785614
5 - 1686 35 329 in forebrain neurons is more abundant than elsewhere in the brain, and the protein resides in both the nucleus as well as the cell body and dendrites 2012 22128154
  • MKRN1 short
  • in mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRNAs at synapses
  • having a PAM2 (PCI/PINT associated module 2)-like motif that mediates its interaction with PABP in an RNA-independent manner
  • stimulates translation in nerve cells
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • distinct arrays of C3H zinc finger (ZF) motifs, a ZF structure with unusual cysteine/histidine spacing
  • a RING domain typically found in E3 ubiquitin ligases
  • two to four zinc fingers
  • a higly conserved RING-H2 zinc finger motif
  • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • located in the cell nuclei and in the cytoplasm and localizes to neurites of nerve cells
  • basic FUNCTION
  • mediating ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
  • transcriptional co-regulator and an E3 ligase
  • exhibits dual functions of keeping cells alive by suppressing TP53 under normal conditions and stimulating cell death by repressing CDKN1A under stress conditions
  • is involved in carcinogenesis of the well-differentiated type of tumors possibly via ubiquitination of FILIP1
  • modulates RNA polymerase II-mediated transcription and may play a role in mRNA decay
  • RING zinc finger protein, exhibiting divergent functions both in the cell nucleus and the cytoplasm
  • in mammalian brain neurons MKRN1-short functions as a modulator of local protein synthesis in dendrites
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, transcription
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • simultaneously functions as a differentially negative regulator of TP53 and CDKN1A
  • binding partner of PABP that interacts with poly(A) binding proteins (PABP) in an RNA-independent manner
  • functions as a novel E3 ligase of CDKN2A and potentially regulates cellular senescence and tumorigenesis in gastric cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS