basic FUNCTION
| mediating ubiquitin-conjugating enzyme (E2)-dependent ubiquitination |
|
transcriptional co-regulator and an E3 ligase |
|
exhibits dual functions of keeping cells alive by suppressing TP53 under normal conditions and stimulating cell death by repressing CDKN1A under stress conditions |
|
is involved in carcinogenesis of the well-differentiated type of tumors possibly via ubiquitination of FILIP1 |
|
modulates RNA polymerase II-mediated transcription and may play a role in mRNA decay |
|
RING zinc finger protein, exhibiting divergent functions both in the cell nucleus and the cytoplasm |
|
in mammalian brain neurons MKRN1-short functions as a modulator of local protein synthesis in dendrites |