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Symbol MKNK2 contributors: mct - updated : 06-05-2015
HGNC name MAP kinase interacting serine/threonine kinase 2
HGNC id 7111
Location 19p13.3      Physical location : 2.037.469 - 2.051.243
Synonym name G protein coupled receptor kinase 7
Synonym symbol(s) GPRK7, MNK2
TYPE functioning gene
STRUCTURE 13.77 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU   long interspersed repetitive elements
MAPPING cloned Y linked N status confirmed
TRANSCRIPTS type messenger
text alternatively spliced yielding two splicing isoforms with differing last exons (PMID: 24726367)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 splicing 1778 46.6 414 ubiquitous, nuclear 2014 24726367
  • Mnk2b, which lacks terminal ERK docking site homolog
  • also called isoform B
  • is pro-oncogenic and does not activate MAPK14, while still enhancing EIF4E phosphorylation
  • 14 splicing 3805 51.7 465 cytoplasmic, downregulated in breast, lung, and colon tumors 2014 24726367
  • aslo called isoform A
  • Mnk2a, which contains a MAPK-binding domain
  • is tumor suppressive
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     stomach   moderately
    Lymphoid/Immunethymus   moderately
     tonsils   moderately
    Nervousnervecranial nerve  predominantly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Visualeye   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period embryo
    Text moderately in embryo
  • a complete serine/threonine kinase domain including a DLG/Asp-Leu-Gly preceded by a DFD (Asp-Phe-Asp) motifs
  • a potential nuclear localization signal (NLS)
  • several potential MAP kinase phosphorylation sites
  • a C terminal ERK docking site homolog
  • conjugated PhosphoP
    mono polymer homomer , monomer
    interspecies homolog to rattus Mknk2 (94.3 pc)
    homolog to murine Mknk2 (95.4 pc)
    intraspecies paralog to MKNK1, other dependent MAP-kinase dependent kinase
  • Ser/Thr protein kinase family
  • CATEGORY enzyme , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • may play a role in the response to environmental stress and cytokines
  • regulating transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap
  • MKNK1, MKNK2 are protein-serine/threonine kinases that are activated by ERK or MAPK14 and phosphorylate EIF4E, which is involved in cap-dependent translation initiation
  • oncogenic role for MKNK1/MKNK2 in tumor development
  • key role for the MKNK1, MKNK2/EIF4E pathway in the regulatory effects of IFNG on normal hematopoiesis
  • plays a unique role, not shared by its closest paralog MKNK1, in limiting protein translation through its negative effect on eIF4G1 Serıı&
  • 8304;&
    8312; phosphorylation and RPS6KB1 activation
  • MKNK1, MKNK2, has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation
  • MKNK1, MKNK2 play important roles in controlling signals involved in mRNA translation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, translation regulation
    signaling signal transduction
  • cell surface receptor linked signal transduction
  • a component
    small molecule metal binding, cofactor, nucleotide,
  • binding to Mg2+
  • binding to Zn2+ (one ion per subunit)
  • ATP
  • protein
  • estrogen receptor beta (ERB)
  • interacting with the C-terminal regions of EIF4G1 and EIF4G2
  • also binding to dephosphorylated ERK1 and ERK2
  • interacting with ESR2 (variant 1)
  • HNRNPA1 recruitment to stress granules involves MKNK1/MKNK2-dependent phosphorylation of mRNA-bound HNRNPA1
  • MKNK1/MKNK2-EIF4G1 interaction is important for EIF4E phosphorylation
  • previously unrecognized role for BANK1 in CpG-induced responses by splenic B cells on MAPK14 signaling and control of translation initiation of IL6 via MKNK1/MKNK2 and EIF4E
  • MKNK1, MKNK2 increased the binding of EIF4E to the cytoplasmic FMR1-interacting protein 1 (CYFIP1), which binds the fragile-X mental retardation protein, FMR1, a translational repressor
  • MKNK1, MKNK2, can modulate oncogenic translation by regulating EIF4E-EIF4E3 levels and activity in diffuse large B-cell lymphoma (DLBCL)
  • MKNK1, MKNK2 increased the binding of EIF4E to the cytoplasmic FMR1-interacting protein 1 (CYFIP1), which binds the fragile-X mental retardation protein, FMR1, a translational repressor
  • cell & other
    Other phosphorylated and activated by ERK1, ERK2