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FLASH GENE
Symbol MIXL1 contributors: - updated : 08-06-2004
HGNC name Mix1 homeobox-like 1 (Xenopus laevis)
HGNC id 13363
Location 1q41      Physical location : 226.411.382 - 226.413.512
Synonym symbol(s) MILD1, MIXL
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)    1  Copie(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
Binding site   transcription factor   HRE
motif repetitive sequence   ALU
text structure a putative initiator region and TATA box as well as potential Smad, FoxH1/FAST, T-box, COUP-TF, C/EBP, GATA, HNF3 binding sites and retinoic acid response elements
MAPPING cloned Y linked Y status provisional
Map cen - D1S479 - MIXL1 - D1S459 - qter
Authors Guo et al.(02)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
Lymphoid/ImmuneB cell
Lymphoid/ImmuneT cell
cell lineage
cell lines mammary carcinoma, germ cell tumors, highly in a diffuse large B-cell lymphoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a homeobox domain
HOMOLOGY
interspecies ortholog to murine Mml
Homologene
FAMILY MIX1-like gene family
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • regulation of transcription
  • could induce expression of alpha-globin gene
  • essential role in embryonic and adult hematopoiesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS