protein
| TYR, TYRP1, DCT |
|
TBX2 not involved in melanogenesis |
|
target of the phosphatidylinositol-3-kinase pathway |
|
key transcription factor for PKC-beta (protein kinase C-beta), required to phosphorylate otherwise inactive tyrosinase |
|
TFE3 and TFEC proteins may collaborate with MITF to efficiently regulate expression of target genes in osteoclasts  |
|
MITF regulation of the cathepsin K, CLCN7, and OSTM1 genes, which are critical for osteoclast resorption, suggesting that MITF may be a master regulator of osteoclast function and bone resorption  |
|
MITF regulation in osteoclasts by PSMD14  |
|
can interact directly with beta-catenin, the key mediator of the canonical Wnt signaling pathway |
|
interaction with 14-3-3 and the kinase MARK3 regulating its movement  |
|
binds and activates a conserved regulatory element upstream of DICER1 transcriptional start site upon melanocyte differentiation  |
|
interacting with ATF2 (importance of transcriptionally active ATF2 in melanoma development through fine-tuning of MITF expression)  |
|
HDAC7 represses MITF at least in part by deacetylation-independent mechanism  |
|
interacting with USP13 (through deubiquitination, USP13 stabilizes and upregulates MITF protein levels)  |
|
transcriptional suppression of the MITF gene by DEC1, a HIF1A target that is recruited to the MITF locus under hypoxia  |
|
HINT1 suppresses specific gene transcription by interacting with the transcription factor MITF in mast cells  |
|
YY1 cooperates with MITF in regulating the expression of piebaldism gene KIT and multiple additional pigmentation genes  |
|
in conjunction with MITF/TFEC, PAX6 acts as an anti-retinogenic factor, whereas in conjunction with retinogenic genes it acts as a pro-retinogenic factor  |
|
PPARGC1A, PPARGC1B coactivators regulate MITF and the tanning response  |
|
target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of PPARGC1A  |
|
BMP4 induces MITF expression in pluripotent stem cells and EDN3 subsequently promotes differentiation of these MITF expressing cells along the melanocyte lineage  |
|
MITF is a critical regulator of GPNMB expression in dendritic cells  |
|
SOX5 has a strong inhibitory effect on MITF expression and seems to have a decisive clinical impact on melanoma during tumor progression  |
|
DDX3X steers MITF protein levels dictating melanoma metastatic potential and response to targeted therapy  |
|
ABCB5 is a direct target for MITF and its expression can be induced by CTNNB1, a key activator and co-factor for MITF, and and is associated with melanoma differentiation  |