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FLASH GENE
Symbol MIRLET7A1 contributors: mct - updated : 07-01-2011
HGNC name microRNA let-7a-1
HGNC id 31476
Location 9q22.32      Physical location : 96.938.238 - 96.938.317
Synonym symbol(s) hsa-let-7a-1, MIRNLET7A1, Let-7
DNA
TYPE small rna
STRUCTURE 0.80 kb     1 Exon(s)
MAPPING cloned   linked N status provisional
RNA
TRANSCRIPTS type untranslated small cytoplasmic
EXPRESSION
Rna function
  • is sufficient to regulate glucose metabolism (PMID;
  • LIN28B–MIRLET7A1–MYCN signaling blocked differentiation of normal neuroblasts and neuroblastoma cells
  • important link between TP53 activation induced by DNA damage and MIRLET7A1 biogenesis
  • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    enhancing LIN28A function or abrogating MIRLET7A1 may be therapeutically promising for diseases like obesity and diabetes
    ANIMAL & CELL MODELS