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FLASH GENE
Symbol MIR184 contributors: mct - updated : 14-11-2011
HGNC name microRNA 184
HGNC id 31555
Corresponding disease
KTCN5 keratoconus 5
Location 15q25.1      Physical location : 79.502.129 - 79.502.212
DNA
TYPE small rna
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type untranslated small nuclear
EXPRESSION
Rna function
  • expressed in the central corneal epithelial basal and suprabasal cells and in the lens epithelium
  • repression by MYCN contributes to tumorigenesis, in part, leading to increased levels of AKT2, a direct target of MIR184
  • role in umbilical cord blood (UCB) CD4+ T cells (potential novel function for microRNA in the early adaptive immune response) (
  • corneal epithelial-specific, and can interfere with the ability of MIR205 to suppress INPPL1 levels
    • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    ASSOCIATED DISORDERS
    corresponding disease(s) KTCN5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    inhibitor of AKT2, miR-184 could be of potential benefit in miRNA mediated therapeutics of MYCN amplified neuroblastoma and other forms of cancer
    ANIMAL & CELL MODELS