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FLASH GENE
Symbol MIR137 contributors: mct - updated : 17-01-2012
HGNC name microRNA 137
HGNC id
Corresponding disease
DEL1P21 chromosome 1p21.3 microdeletion
Location 1p21.3      Physical location : 98.511.626 - 98.511.727
Synonym symbol(s) MIRN137
DNA
TYPE small rna
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type
EXPRESSION
Rna function
  • plays an essential role in cell-cycle control at the G1/S-phase checkpoint
  • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1P21
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expression in melanoma cell lines was found to inversely correlate with CTBP1 levels
    constitutional     --low  
    in gastric cancer and is a negative regulator of CDC42
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MIR137 promoter methylation has potential utility as a prognostic marker for squamous cell carcinoma of the head and neck
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    SPTLC1, SPTLC2, SPTLC3 and MIR137 may be potential therapeutic targets for sporadic Alzheimer disease
    ANIMAL & CELL MODELS