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FLASH GENE
Symbol MIPEP contributors: mct - updated : 06-06-2019
HGNC name mitochondrial intermediate peptidase
HGNC id 7104
Corresponding disease
COXPD31 combined oxidative phosphorylation deficiency 31
Location 13q12.12      Physical location : 24.304.328 - 24.463.587
Synonym symbol(s) HMIP, MIP, PMIP, COXPD31
EC.number 3.4.24.59
DNA
TYPE functioning gene
STRUCTURE 159.26 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC390382 13 similar to histone 1, H2bc; H2B histone family, member S FLJ34588 13q12.11 Smhs2 homolog (rat) LOC387907 13 similar to bA271B5.1 (similar to ribosomal protein S7) FGF9 13q11-q12 fibroblast growth factor 9 (glia-activating factor) LOC387908 13 similar to Ferritin heavy chain (Ferritin H subunit) LOC390383 13 similar to inositol polyphosphate multikinase LOC387909 13 hypothetical gene supported by AK130366 LOC283530 13q12.12 hypothetical LOC283530 LOC387910 13 LOC387910 SGCG 13q12 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) SACS 13q12 spastic ataxia of Charlevoix-Saguenay (sacsin) TNFRSF19 13q12.11-q12.3 tumor necrosis factor receptor superfamily, member 19 MIPEP 13q12 mitochondrial intermediate peptidase LOC387911 13 similar to hypothetical protein MGC48915 LOC390384 13 similar to hypothetical protein DKFZp434A171 SPATA13 13q12.13 spermatogenesis associated 13 MGC48915 13q12.13 hypothetical protein MGC48915 LOC390385 13 similar to hypothetical protein, MGC:7199 HCP33 13q12.13 cytochrome c, somatic pseudogene ADPRTL1 13q11 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 LOC387912 13 similar to TPTE and PTEN homologous inositol lipid phosphatase ATP12A 13q12.1-q12.3 ATPase, H+/K+ transporting, nongastric, alpha polypeptide LOC390386 13 similar to hypothetical protein DKFZp434A171 RNF17 13q12 ring finger protein 17 TDRD4 13q12.12 tudor domain containing 4 CENPJ 13q12.13 centromere protein J LOC387913 13 similar to TPTE and PTEN homologous inositol lipid phosphatase LOC390387 13 similar to Striatin PABPC3 13q11-q12 poly(A) binding protein, cytoplasmic 3 FLJ25477 13q12.13 hypothetical protein FLJ25477 MTMR6 13q12 myotubularin related protein 6 NUPL1 13q12.12 nucleoporin like 1 LOC246717 13q12 transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene ATP8A2 13q12-13 ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 LOC387914 13 similar to WGAR9166
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2361 - 713 - 2016 27799064
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx   highly
Endocrinepancreas    
 parathyroid   highly
Nervousbrainhindbraincerebellum  
 brain    
 spinal cord    
Reproductivefemale systembreastmammary gland highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
mono polymer monomer
HOMOLOGY
interspecies homolog to C.elegans f32b6,2
homolog to Rattus norvegicus mitochondrial intermediate peptidase
Homologene
FAMILY peptidase family m3
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • mitochondrial intermediate peptidase
  • involved in the biogenesis of the oxidative phosphorylation system
  • metalloendopeptidase
  • both BCL11A and MIPEP were associated with increased endogenous levels of HbF
  • is a novel regulator of SIRT3 activation by caloric restriction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • gamma-secretase-regulated proteolysis of the Notch receptor by MIPEP
  • MIPEP may contribute to the maintenance of mitochondrial quality during caloric restriction (CR) via activation of SIRT3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD31
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS