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FLASH GENE
Symbol MINK1 contributors: mct - updated : 17-02-2014
HGNC name misshapen-like kinase 1 (zebrafish)
HGNC id 17565
Location 17p13.2      Physical location : 4.736.634 - 4.801.355
Synonym name
  • germinal center kinase
  • GCK family kinase MINK
  • misshapen/NIKS related kinase
  • Synonym symbol(s) B55, MAP4K6, MGC21111, MINK, YSK2, ZC3, hMINK
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 58.78 kb     32 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 4924 - 1295 - 2004 15469942
    32 - 4948 - 1303 - 2004 15469942
    32 - 5035 - 1332 - 2004 15469942
    32 - 4975 - 1312 ubiquitous 2004 15469942
  • MINK beta
  • moderately activates c-Jun N-terminal kinase
  • colocalizing with the Golgi apparatus
  • plays an important role in cytoskeleton reorganization, cell adhesion, and cell motility
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunetonsils   highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text various developmental stages brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal kinase domain
  • a proline rich intermediate region
  • C terminal GCK homology region
  • HOMOLOGY
    Homologene
    FAMILY germinal center kinase (GCK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be playing an important role in cytoskeleton reorganization, cell adhesion, and cell motility
  • selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection
  • playinga a role as a specific effector of RAP2A in the brain (Nonaka 2008)
  • expression of MINK1 and TRAF2 in neurons is required for normal dendritic arborization and surface expression of AMPA receptors
  • phosphorylates and regulates its RAB5-dependent endosomal trafficking, a process required for the localized plasma membrane accumulation and function of PRICKLE1)
  • regulate cytoskeletal organization and oncogene-induced cell senescence
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text brain
    PATHWAY
    metabolism
    signaling
    a component
  • of STE20 group of mitogen-activated protein kinase kinase kinase kinases (Nonaka 2008)
  • a component of STRIPAK
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAP2A (RAP2A-interacting protein enriched in brain) ((Nonaka 2008)
  • interacting with TANC1 (scaffold protein that interacts with various postsynaptic scaffold and cytoskeletal proteins, including PSD-95 and SAP97)(Nonaka 2008)
  • MINK1 interaction with RAP2B plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission
  • MINK1 is a PRICKLE1-associated protein
  • link between MINK1 and the VANGL2-PRICKLE1 complex and importance of PRICKLE1 phosphorylation and endosomal trafficking for its function during WNT-PCP signaling
  • MINK1 directly interacted with STRN4 (STRN4 reduced MINK1 activity in the presence of catalytic and structural subunits of PPP2CA)
  • cell & other
    REGULATION
    Other upregulated during postnatal development of the brain
    activation of C Jun N terminal kinase and of the p38 pathways
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS