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FLASH GENE
Symbol MIER1 contributors: - updated : 04-03-2006
HGNC name mesoderm induction early response 1 homolog (Xenopus laevis)
HGNC id 29657
Location 1p31.3      Physical location : 67.390.577 - 67.454.302
Synonym name
  • mesoderm induction early response 1
  • mesoderm induction early response 1 N1-beta- ii
  • mesoderm induction early response 1 N2-beta- ii
  • Synonym symbol(s) ER1, KIAA1610, MI-ER1, RP5-944N15.1, MGC131940
    DNA
    TYPE functioning gene
    STRUCTURE 63.00 kb     16 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • includes one skipped exon, a facultative intron and three polyadenylation signals to produce 12 transcripts encoding six distinct proteins
  • several putative Sp1 binding sites
  • promoter region contains a CpG island but lacks an identifiable TATA element, initiator sequence and downstream promoter element
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1804 - 457 - Paterno
    lacking the predicted nuclear localization signal and unlike hMI-ER1beta, it is not a nuclear protein, but remains in the cytoplasm
    - - 2629 60 536 in all tissues except testis Paterno
    - - 1729 - 432 - Paterno
    lacking the predicted nuclear localization signal and unlike hMI-ER1beta, it is not a nuclear protein, but remains in the cytoplasm
    - - 1648 - 433 - Paterno
    lacking the predicted nuclear localization signal and unlike hMI-ER1beta, it is not a nuclear protein, but remains in the cytoplasm
    - - 2554 - 511 in all tissues except testis Paterno
    nuclear protein
    - - 2473 - 536 in all tissues except testis Paterno
    nuclear protein
    - - 3455 - 512 in all tissues except testis Paterno
    nuclear protein
    - - 3536 - 511 in all tissues except testis Paterno
    nuclear protein
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one ELM2 domain
  • one Myb DNA-binding domain
  • a SANT domain, playing a functional role in the action of co-repressor regulatory factors
  • HOMOLOGY
    interspecies homolog to chimpanzee LOC4693471
    ortholog to murine Mier1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear protein,or remaining in the cytoplasm
    basic FUNCTION
  • fibroblast growth factor-inducible early response gene activated during mesoderm induction and encoding a nuclear protein that functions as a transcriptional activator
  • repressing Sp1-activated transcription from the minimal promoter by a histone deacetylase-independent mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with SP1 (represents a novel mechanism for the negative regulation of SP1 target promoters)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS