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FLASH GENE
Symbol MID2 contributors: KTN/npt - updated : 02-02-2009
HGNC name midline 2
HGNC id 7096
Location Xq22.3      Physical location : 107.069.083 - 107.174.865
Synonym name
  • tripartite motif protein 1
  • RING finger protein 60
  • dJ820B18.2 (midline 1 (Opitz/BBB syndrome))
  • midin 2
    • Synonym symbol(s) FXY2, TRIM1, MID1, RNF60
    DNA
    TYPE functioning gene
    STRUCTURE 100.96 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - BTK - DRP2 - GLA - TIMM8A - DXS101 - PLP1 - SERPINA7 - DXS1230 - DXS1120 - DXS6793 /MID2 - COL4A6 - COL4A5 - DXS1210 - PRPS1 PRPS1 - qter
    Authors Buchner (99) Perry (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 7345 83 735 - Buchner (1999)
    10 splicing 7255 79.7 705 - Buchner (1999)
    lacking 90 nt form an internal exon
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text tissues, noteworthy in developing heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal RING finger
  • two B box domains, linked to a leucine coiled-coil domain (RBCC subgroup) the so-called tripartite motif (TRIM) mediating homodimerization, characteristic of the B box family of proteins, involved in cell proliferation and development
  • a COS (C-terminal subgrooup one signature) domain
  • a fibronectin type III domain between the RBCC
  • the C terminal B30-2/SPRY or RFP-like domain
    • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Mid2 (99.3 pc)
    homolog to rattus Mid2 (99.1 pc)
    intraspecies homolog to MID1
    Homologene
    FAMILY
  • TRIM/RBCC family
  • B box family TRIM subfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • playing a role in embryonic development
  • acting as an antiretroviral factor (Ozato 2008)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with MID1 (Short 2002)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with IGBP1
  • interacting with PPP2R4 (Short 2002)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for X-linked FG (Opitz-Kaveggia) syndrome (Short 2002, Ozato 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS