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FLASH GENE
Symbol MICU2 contributors: mct - updated : 30-05-2016
HGNC name mitochondrial calcium uptake 2
HGNC id 31830
Location 13q12.11      Physical location : -
Synonym name
  • Smhs2 homolog (rat)
  • doublecortin and CaM kinase-like 1
  • EF-hand domain family, member A1
  • Synonym symbol(s) DCAMKL1, FLJ34588, EFHA1
    DNA
    TYPE functioning gene
    STRUCTURE 111.53 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1947 - 434 - 2014 24560927
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  moderately
     parathyroid   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 360 amino acid C-terminal domain encoding a putative Ca2+/calmodulin-dependent protein kinase
  • EF-hand domains
  • HOMOLOGY
    interspecies ortholog to murine Efha1 (87.2pc)
    intraspecies homolog to DCX
    paralog to MICU1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may regulate microtubules
  • mediating a phosphorylation-dependent signal transduction pathway
  • encoding a functional kinase capable of phosphorylating myelin basic protein and itself
  • is a new component of the uniporter complex that may contribute to the tissue-specific regulation of this channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • SMDT1 was required for the interaction of MCU with MICU1 and MICU2
  • MICU1 physically associates with and is co-expressed with a paralog, MICU2
  • SMDT1-dependent regulation of MCU channel activity requires intermembrane space-localized MICU1, MICU2, and cytoplasmic Ca(2+)
  • SMDT1 second function is to maintain tight MICU1, MICU2 regulation of the MCU pore, a role that requires SMDT1 to bind MICU1 using its conserved C-terminal polyaspartate tail
  • cell & other
    REGULATION
    Other both MICU1 and MICU2 are regulated by calcium through their EF-hand domains, thus accounting for the sigmoidal response of MCU to [Ca(2+)] in situ and allowing tight physiological control
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS