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FLASH GENE
Symbol MICALL2 contributors: mct - updated : 06-05-2011
HGNC name MICAL-like 2
HGNC id 29672
Location 7p22.3      Physical location : 1.473.995 - 1.499.109
Genatlas name molecules interacting with CasL-like 2
Synonym name
  • junctional Rab13-binding protein
  • Synonym symbol(s) FLJ44858, MGC46023, FLJ23471, MICAL-L2, JRAB, FLJ41996, FLJ45410
    DNA
    TYPE functioning gene
    STRUCTURE 25.11 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 3144 97 904 - 2002 12110185
    - splicing 2474 75 704 - 2002 12110185
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
    Lymphoid/Immunespleen   predominantly
    Reproductivefemale systembreastmammary gland moderately
     male systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal calponin-homology (CH)
  • a LIM zinc-binding domain
  • a flavoprotein monooxygenase domain
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • may be a cytoskeletal regulator
  • potentially mediates the endocytic recycling of occludin and the formation of functional TJs (tight junctions) by linking RAB13 to actin cytoskeleton
  • RAB13 and MICALL2 are involved in epithelial cell scattering
  • with RAB13, mediated the endocytic recycling of an integral tight junctions (TJ) protein occludin and the formation of functional TJs
  • RAB13 and MICALL2 may potentially act to transfer actinin-4 from the cell body to the tips of neurites, where actinin-4 is involved in the reorganization of the actin cytoskeleton which results in neurite outgrowth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • RAB13 effector protein (intramolecular interaction between the N-terminal calponin-homology (CH) and LIM domains of MICALL2 and the C-terminal coiled-coil domain of RAB13)
  • interaction of MICALL2 with RAB8A and RAB13 coordinates the assembly of adherens junctions and tight junctions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS