Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MICALL1 contributors: mct - updated : 23-10-2012
HGNC name MICAL-like 1
HGNC id 29804
Location 22q13.1      Physical location : 38.302.345 - 38.338.025
Synonym name molecule interacting with Rab13
Synonym symbol(s) KIAA1668, bA395L14.2, MIRAB13, MICAL-L1, DKFZp686M2226, FLJ45921
DNA
TYPE functioning gene
STRUCTURE 36.31 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4495 93 863 - 2002 12110185
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Reproductivefemale systemuteruscervix  
 female systemovary   
 male systemtestis   
 male systemprostate   
Respiratoryrespiratory tractlarynx   
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal CH domain (calponin homology) associates with the C-terminal RAB13 binding domain (RBD)
  • a LIM, proline rich and coiled-coil domains
  • C-terminal RAB13 binding domain (RBD), and coiled-coil region necessary and sufficient for its localization to tubular membranes
  • HOMOLOGY
    Homologene
    FAMILY MICAL-family of proteins
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton
    text
  • associated with late endosomes
  • basic FUNCTION
  • essential for efficient endocytic recycling
  • unusual type of RAB effector that regulates endocytic recycling by recruiting and linking EHD1 and RAB8A on membrane tubules
  • MICALL1/Rab protein complex can regulate EGFR trafficking at late endocytic pathways
  • RAB35 is a critical upstream regulator of MICALL1 and ARF6, while both MICALL1 and ARF6 regulate RAB8A function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ARF6 forms a complex with MICALL1 and plays a role in its recruitment to tubular endosome
  • RAB35 forms a tripartite complex with MICALL1 and ACAP2 and recruits them to perinuclear ARF6-positive endosomes in response to nerve growth factor stimulation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB8-interacting protein, MICALL1, associates with EHD1, with both proteins colocalizing to long tubular membranes
  • RAB35 is a MICALL1-binding partner (over-expression of active RAB35 impairs the recruitment of MICALL1 to tubular recycling endosomes, whereas RAB35 depletion promotes enhanced MICALL1 localization to these structures)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS