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FLASH GENE
Symbol MICAL3 contributors: mct - updated : 19-09-2012
HGNC name microtubule associated monoxygenase, calponin and LIM domain containing 3
HGNC id 24694
Location 22q11.21      Physical location : 18.270.417 - 18.507.325
Synonym name
  • molecule interacting with CasL protein 3
  • flavoprotein oxidoreductase MICAL3
  • Synonym symbol(s) KIAA0819, KIAA1364
    EC.number 1.14.13.-
    DNA
    TYPE functioning gene
    STRUCTURE 236.91 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned N linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 9471 - 2002 - 2002 12110185
    21 - 3384 - 966 - 2002 12110185
    23 - 8091 - 1073 - 2002 12110185
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  lowly
     intestinelarge intestinecolon moderately
    Lymphoid/Immunelymph node   highly
     spleen   moderately
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
     respiratory tractlarynx  lowly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal monooxygenase domain containing flavin adenine dinucleotide (FAD)-binding motifs
  • a calponin-homology (CH) domain
  • a LIM zinc-binding domain
  • an ERM alpha domain-like coiled-coil motif
  • conjugated FlavoP
    HOMOLOGY
    interspecies ortholog to murine Mical3
    homolog to drosophila MICAL
    Homologene
    FAMILY MICAL family of flavoprotein monooxygenases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • associated with spermatid development
  • acting as a monooxygenase
  • involved in neuronal regeneration
  • conserved family of cytosolic multidomain proteins that has been shown to be associated with a variety of cellular processes, including axon guidance, cell movement, cell-cell junction formation, vesicle trafficking and cancer cell metastasis
  • possible role for MICAL genes in cardiovascular development
  • RAB6A, RAB8A, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
  • MICAL1, MICAL2, MICAL3, are required for normal actin organization, and all three MICALs regulate actin stress fibers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , electron transport
    text
  • spermatid development
  • PATHWAY
    metabolism other
    signaling
  • aromatic compound metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • FAD
  • Zn2+
  • protein
  • RAB8A8A and ERC1 can be linked by MICAL3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS