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FLASH GENE
Symbol MICAL2 contributors: mct - updated : 19-09-2012
HGNC name microtubule associated monoxygenase, calponin and LIM domain containing 2
HGNC id 24693
Location 11p15.3      Physical location : 12.132.137 - 12.285.329
Synonym name
  • flavoprotein oxidoreductase MICAL2
  • protein-methionine sulfoxide oxidase MICAL2
  • molecule interacting with CasL2
  • Synonym symbol(s) KIAA0750, DKFZp686H03148, DKFZp686H2469, MICAL2PV1, MICAL2PV2, MICAL-2
    DNA
    TYPE functioning gene
    STRUCTURE 153.19 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a LOC387753 11 similar to 60S ribosomal protein L21 SWAP70 11p15 Homo sapiens SWAP-70 protein (SWAP70), mRNA. CMT4B2 11p15.3 Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding) ADM 11p15.4 adrenomedullin LOC338749 11p15.3 hypothetical LOC338749 AMPD3 11p15 adenosine monophosphate deaminase (isoform E) RNF141 11p15.3 ring finger protein 141 XLKD1 11p15 extracellular link domain containing 1 MRVI1 11p15 murine retrovirus integration site 1 homolog SH2BP1 11pter-p15.4 SH2 domain binding protein 1 (tetratricopeptide repeat containing) EIF4G2 11p15 eukaryotic translation initiation factor 4 gamma, 2 LOC58486 11p15.3 transposon-derived Buster1 transposase-like protein MGC71806 11p15.3 similar to Hypothetical protein LOC233733 USP47 11p15.2 ubiquitin specific protease 47 RIG 11p15.1 ubiquitin specific protease 47 DKK3 11p15.2 dickkopf homolog 3 (Xenopus laevis) MICAL2 11p15.2 dickkopf homolog 3 (Xenopus laevis) FLJ14966 11p15.3 hypothetical protein FLJ14966 PARVA 11p15.2 parvin, alpha TEAD1 11p15.2 TEA domain family member 1 (SV40 transcriptional enhancer factor) LOC119593 11p15.3 similar to RIKEN cDNA 4632411J06 ARNTL 11p15 aryl hydrocarbon receptor nuclear translocator-like GMRP-1 11p15.3-p15.2 K+ channel tetramerization protein PTH 11p15.2-p15.1 parathyroid hormone FLJ22728 11p15.2 hypothetical protein FLJ22728 LOC338750 11p15.2 similar to hypothetical protein FLJ33167 LOC387754 11 LOC387754 SPON1 11p15.2-p14 spondin 1, (f-spondin) extracellular matrix protein RRAS2 11p15.2 related RAS viral (r-ras) oncogene homolog 2 LOC390094 11 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein COPB 11p15.4-p15.2 coatomer protein complex, subunit beta PSMA1 11p15.1 proteasome (prosome, macropain) subunit, alpha type, 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3934 126.5 1124 - 2002 12110185
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveliver   lowly
    Nervousbrain   predominantly
    Reproductivefemale systemovary  lowly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a LIM domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG11685
    Homologene
    FAMILY MICAL family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • having a monooxygenase activity
  • involved in neuronal regeneration
  • conserved family of cytosolic multidomain proteins that has been shown to be associated with a variety of cellular processes, including axon guidance, cell movement, cell-cell junction formation, vesicle trafficking and cancer cell metastasis
  • possible role for MICAL genes in cardiovascular development
  • MICAL1, MICAL2, MICAL3, are required for normal actin organization, and all three MICALs regulate actin stress fibers
  • differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation
  • atypical actin-regulatory protein, mediating SRF/MKL1-dependent gene transcription elicited by nerve growth factor and serum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism other
    signaling
    aromatic compound metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • induces redox-dependent depolymerization of nuclear actin, which decreases nuclear G-actin and increases MKL1 in the nucleus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS