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FLASH GENE
Symbol MICAL1 contributors: mct - updated : 25-08-2012
HGNC name microtubule associated monoxygenase, calponin and LIM domain containing 1
HGNC id 20619
Location 6q21      Physical location : 109.765.267 - 109.777.190
Synonym name
  • CasL interacting molecule
  • NEDD9 interacting protein with calponin homology and LIM domains
  • protein-methionine sulfoxide oxidase MICAL1
  • Synonym symbol(s) MICAL, FLJ11937, DKFZp434B1517, FLJ21739, NICAL, MICAL-1
    DNA
    TYPE functioning gene
    STRUCTURE 11.93 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3661 118 1067 - 2003 12788069
  • MICAL1a
  • 24 splicing 3403 - 981 - 2003 12788069
  • MICAL-1b
  • specifically interacts with RAB1A in a nucleotide-dependent manner
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunethymus    
    Reproductivefemale systemuterus   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    cell lineage
    cell lines hematopoietic cell lines Jurkat
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FAD binding domain
  • a calponin homology domain
  • a LIM domain
  • a putative leucine zipper motif
  • a proline-rich PPKPP sequence
  • C-terminal coiled-coil region, implicated in its auto-inhibition
  • secondary structure
  • calpolnin homology (CH) domain is composed of six alpha helices and one 3(10) helix
  • HOMOLOGY
    Homologene
    FAMILY MICAL family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text localizes along with vimentin intermediate filaments
    basic FUNCTION
  • may be a cytoskeletal regulator that connects NEDD9 to intermediate filaments
  • involved in neuronal regeneration
  • conserved family of cytosolic multidomain proteins that has been shown to be associated with a variety of cellular processes, including axon guidance, cell movement, cell-cell junction formation, vesicle trafficking and cancer cell metastasis
  • possible role for MICAL genes in cardiovascular development
  • F-actin-disassembly factor that is critical in actin reorganization
  • as an effect factor participated in F-actin disassemble, may associate with inner pathophysiological modulation in epilepsy
  • physiological role of MICAL1 in apoptosis
  • MICAL1, MICAL2, MICAL3, are required for normal actin organization, and all three MICALs regulate actin stress fibers
  • differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • protein
  • vimentin
  • interacts with the SH3 domain of NEDD9
  • interaction of MICAL1 and RAB1A might provide a link between the Golgi apparatus and the intermediate filament cytoskeleton
  • interacts with rab1 in a nucleotide dependent-manner
  • binding partner of NDR (nuclear Dbf2-related) kinases, STK4, and STK38
  • competes with STK4 for NDR binding and thereby antagonizes MST1-induced NDR activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS