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FLASH GENE
Symbol MIB1 contributors: mct - updated : 20-06-2016
HGNC name mindbomb homolog 1 (Drosophila)
HGNC id 21086
Location 18q11.2      Physical location : 19.321.544 - 19.450.910
Synonym name
  • ubiquitin ligase mind bomb
  • DAPK-interacting protein 1
  • zinc finger ZZ type with ankyrin repeat domain protein 2
    • Synonym symbol(s) DIP-1, KIAA1323, MIB, ZZZ6, ZZANK2
    DNA
    TYPE functioning gene
    STRUCTURE 129.37 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 9308 - 1006 - 2009 19710364
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
     spinal cord   highly
    Reproductivefemale systemovary  highly
    Urinarybladder   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger
  • nine ankyrin repeats
  • three RING fingers
  • an alpha-helical coiled-coil region between RING2 and RING3
    • HOMOLOGY
    interspecies ortholog to murine Mib1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • involved in protein ubiquitination
  • its activity is required for S3 cleavage of the NOTCH1 receptor
  • essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development
  • potentially important for intraembryonic hematopoiesis not only in the aortic endothelium but also in the the floor of the aorta and subaortic patches
  • essential E3 ligase in T and marginal zone B cell development, through the regulation of Notch ligands in the thymic and splenic microenvironments
  • multidomain E3 ligase that directs ubiquitination of the Notch ligands Delta and Jagged to promote their endocytosis
  • sufficient to activate WNT/CTNNB1 signaling and that this activity depends on endogenous RYK
  • both RYK and MIB1 are required for Wnt-3A-mediated activation of CTNNB1
  • is required for correct proximodistal (P-D) patterning of the developing pancreas and beta-cell formation
  • MIB1 modulates dynamin recruitment by regulating the interaction between SNX18 and DNM2, thereby helping to ensure the efficient signaling activity of Notch ligands
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • interaction between MIB1 and CFLAR decreases the association of caspase-8 with CFLAR, which activates caspase-8 and induces cell death
  • vRYK both physically and functionally interacts with the E3 ubiquitin ligase Mindbomb 1 (MIB1)
  • is a new component of centriolar satellites, which interacts with and ubiquitylates CEP131 and PCM1 and suppresses primary cilium formation
  • interaction between MIB1 and PLK4 is a new and important element in the control of centriole homeostasis
  • ubiquitin ligase MIB1 plays essential roles in Notch signaling via Notch ligand ubiquitination
  • MIB1 promotes the interaction between DNM2 and SNX18 in an ubiquitin ligase activity-dependent manner
  • PCM1 is essential for tethering the E3 ligase, Mindbomb1 (MIB1), to satellites
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    abrogated T and marginal zone B (MZB) cell development in the lymphopoietic niches
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS