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FLASH GENE
Symbol MGST2 contributors: mct - updated : 15-05-2008
HGNC name microsomal glutathione S-transferase 2
HGNC id 7063
Location 4q28-q31      Physical location : 140.586.921 - 140.625.404
Synonym symbol(s) GST2, MGST-II, FLJ27438, MGC14097
EC.number 2.5.1.18
DNA
TYPE functioning gene
STRUCTURE 38.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC152620 4q28.3 similar to telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1; telomeric repeat binding protein 1 LOC391701 4 similar to ribosomal protein S23 SLC7A11 4q28-q32 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 LOC152594 4q28.3 similar to ART-4 protein CCRN4L 4q28.3 CCR4 carbon catabolite repression 4-like (S. cerevisiae) ELF2 4q28 E74-like factor 2 (ets domain transcription factor) LOC389224 4 hypothetical gene supported by AK097799 OSAP 4q31.1 ovary-specific acidic protein NDUFC1 4q28.2-q28.3 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa TBDN100 4q31.1 transcriptional coactivator tubedown-100 RAB33B 4q28 RAB33B, member RAS oncogene family SET7 4q28 SET domain-containing protein 7 MGST2 4q28-q31 microsomal glutathione S-transferase 2 MAML3 4q28 mastermind-like 3 (Drosophila) SCOC 4q28.3 short coiled-coil protein LOC391702 4 similar to ribosomal protein L14; 60S ribosomal protein L14 CLGN 4q28.3-q31.1 calmegin LOC152586 4q31.1 similar to RIKEN cDNA 4933434I20 MGC10084 4q31.1 hypothetical protein MGC10084 UCP1 4q28-q31 uncoupling protein 1 (mitochondrial, proton carrier) KIAA0882 4q31.1 KIAA0882 protein LOC389225 4 LOC389225 LOC389226 4 similar to ring finger protein 130; g1-related zinc finger protein RNF150 4q31.1 ring finger protein 150 LOC389227 4 LOC389227 ZNF330 4q31.1-q31.2 LOC389227 LOC389228 4 similar to GRIK2 protein IL15 4q31 interleukin 15 INPP4B 4q31.11 inositol polyphosphate-4-phosphatase, type II, 105kDa USP38 4q31.1 ubiquitin specific protease 38
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 802 - 147 - Yang (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , trimer
HOMOLOGY
interspecies homolog to murine Mgst2
Homologene
FAMILY mapeg family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • glutathione-S-transferase 2
  • involved in leukotriene biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis (rare form)
    Variant & Polymorphism other variant increasng the risk of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS