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FLASH GENE
Symbol MGST2 contributors: mct - updated : 15-05-2008
HGNC name microsomal glutathione S-transferase 2
HGNC id 7063
Location 4q28-q31      Physical location : 140.586.921 - 140.625.404
Synonym symbol(s) GST2, MGST-II, FLJ27438, MGC14097
EC.number 2.5.1.18
DNA
TYPE functioning gene
STRUCTURE 38.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 802 - 147 - Yang (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , trimer
HOMOLOGY
interspecies homolog to murine Mgst2
Homologene
FAMILY mapeg family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • glutathione-S-transferase 2
  • involved in leukotriene biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis (rare form)
    Variant & Polymorphism other variant increasng the risk of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS