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FLASH GENE
Symbol MGAT5B contributors: mct - updated : 22-08-2012
HGNC name mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
HGNC id 24140
Location 17q25.2      Physical location : 74.864.797 - 74.946.470
Synonym name
  • N-acetylglucosaminyltransferase IX
  • beta(1,6)-N-acetylglucosaminyltransferase IX
    • Synonym symbol(s) GnT-IX, GnT-VB, FLJ25132
    EC.number 2.4.1.155
    DNA
    TYPE functioning gene
    STRUCTURE 81.67 kb     20 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • two nuclear proteins, CTCF and NeuroD1, which bound to and activated the promoter in neural cells
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text alternative promoters and a dominant mRNA isoform of the gene (PMID: 21771782)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4246 89 790 - Inamori
    16 - 4068 - 801 - Inamori
    18 - 4252 - 792 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    Nervousperipherous    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to MGAT5
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • responsible for the synthesis of a unique oligosaccharide structure in the brain
  • with POMGNT1, enzymes involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells
  • its expression enhances neurite outgrowth on laminin.
  • synthesize both GlcNAcbeta1,6Man branched N- and O-glycans
  • intrinsic and specific role in the nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MGAT5B-mediated glycosylation of PTPRZ1 promotes galectin-1 binding and PTPRZ1 levels of retention on the cell surface
  • interacting with CTCF (transcription of MGAT5B is mediated by the binding of CTCF)
  • ENPP3 is a inhibitor for MGAT5B, which catalyzes the hydrolysis of the nucleotide sugar donor substrate UDP-GlcNAc
    • cell & other
    REGULATION
    activated by CTCF and NEUROD1 (CTCF and NEUROD1 involved in the activation of MGAT5B expression)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS