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FLASH GENE
Symbol MGAT5 contributors: mct/npt/pgu - updated : 27-10-2009
HGNC name mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
HGNC id 7049
Location 2q21      Physical location : 135.011.829 - 135.206.468
Synonym name
  • GlcNAc-T V
  • beta-1,6-N-acetyl-glucosaminyltransferase
  • Synonym symbol(s) GNT5, NAGT5, GNT-V, GNT-VA
    EC.number 2.4.1.155
    DNA
    TYPE functioning gene
    STRUCTURE 194.64 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389046 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389047 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC129439 2q21.2 similar to FKSG30 LOC391444 2 similar to mKIAA0767 protein LOC389048 2 LOC389048 AF038169 2q21.2 hypothetical protein AF038169 LOC389049 2 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) LOC389050 2 LOC389050 LOC389051 2 LOC389051 LOC163336 2q21.2 similar to FLJ10101 protein LOC391445 2 similar to PRED65 LOC389052 2 similar to breast cancer antigen NY-BR-1 LOC391446 2 similar to rRNA intron-encoded homing endonuclease LOC391447 2 similar to zinc finger protein 285 GPR39 2q21 G protein-coupled receptor 39 MGC29643 2q21.2 hypothetical protein MGC29643 NAP5 2q21.2 Nck-associated protein 5 MGAT5 2q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase DKFZP566N034 2q21.3 hypothetical protein DKFZp566N034 ACMSD 2q21.3 aminocarboxymuconate semialdehyde decarboxylase CCNT2 2q21 cyclin T2 FLJ23074 2q21.3 hypothetical protein FLJ23074 DKFZP434B1727 2q21.3 hypothetical protein DKFZp434B1727 R3HDM 2q21.2 R3H domain (binds single-stranded nucleic acids) containing UBXD2 2p14-q21.3 UBX domain containing 2 LCT 2q21 lactase MCM6 2q21 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) LOC391448 2 similar to hypothetical protein FLJ31434 DARS 2q21-q22.3 aspartyl-tRNA synthetase CXCR4 2q21 chemokine (C-X-C motif) receptor 4 LOC389053 2 similar to heterogeneous nuclear ribonucleoprotein K UBBP1 17p12-p11.2 ubiquitin B pseudogene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2421 - 741 - 2009 19403558
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrineadrenal gland    
    Hearing/Equilibriumear    
    Lymphoid/Immunespleen    
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Mgat5 (97.3pc)
    homolog to rattus Mgat5 (97.3pc)
    intraspecies homolog to MGAT5
    Homologene
    FAMILY
  • glycosyltransferase 18 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • key enzyme that catalyzes beta(1-6) branching of N-acetylglucosamine on N-glycan of cell proteins, some of which are linked with metastasis
  • involved in the synthesis of protein-bound and lipid-bound oligosaccharides
  • one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides
  • involved in growth factor receptor signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MGAT3, CDH1 (regulatory mechanism between CDH1, MGAT3 and MGAT5 by enzymatic competition which could underlie a possible novel signaling pathway in carcinogenesis)
  • cell & other
    REGULATION
    activated by DNA hypermethylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    increase in MGAT5 enzyme activity may correlate with the progression of invasive malignancies
    tumoral     --over  
    in gastric cancer with metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS