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FLASH GENE
Symbol MGAT4C contributors: mct - updated : 20-02-2013
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
HGNC id 30871
Location 12q21      Physical location : 86.373.038 - 87.232.681
Synonym name
  • UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1, 4-N-acetylglucosaminyltransferase IV-homolog
  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc
  • Synonym symbol(s) GNTIVH, HGNT-IV-H, GnT-IVc
    EC.number 2.4.1.145
    DNA
    TYPE functioning gene
    STRUCTURE 860.00 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2565 56 478 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrainforebraincerebral lobefrontal lobe 
     braindiencephalonhypothalamus  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly hydrophobic N-terminal region, which may be a transmembrane domain
  • a hydrophilic region, which may be a stem region
  • lacking the proline-rich stem sequence found in other N-acetylglucosaminyltransferases
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyltransferase 54 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • glycosyltransferase involved in catalyzing GlcNAc beta14 linkage to the core mannose residues of N-glycans for tri- or tetraantennary N-glycan structures
  • predicted glycosyltransferase, implicated in PROM1 N-glycosylation
  • may have potentially an important role in certain cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • positive regulator of cell surface PROM1 expression
  • PROM1 acts as an MGAT4C substrate for complex N-glycan processing, which contributes to cell surface PROM1 recognition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS