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FLASH GENE
Symbol MGAT4B contributors: npt - updated : 29-04-2006
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
HGNC id 7048
Location 5q35      Physical location : 179.224.599 - 179.233.952
Synonym name
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B
  • GlcNAc-T IVb
  • UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV
  • Synonym symbol(s) GNT-IV, GNT-IVB
    EC.number 2.4.1.145
    DNA
    TYPE functioning gene
    STRUCTURE 9.84 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391856 5 similar to acetoacetyl-CoA synthetase; acetoacetate-CoA ligase; homolog of C. elegans supressor of ras 5 (sur-5) LOC391857 5 similar to hypothetical protein MGC2574 ZNF354B 5q35-3 zinc finger protein 354B LOC340042 5q35.3 similar to hypothetical protein MGC48972 PIGFP1 5q35 phosphatidylinositol glycan, class F, pseudogene 1 FLJ21628 5q35.3 hypothetical protein FLJ21628 ZNF454 5q35.3 zinc finger protein 454 GRM6 5q35 glutamate receptor, metabotropic 6 LOC391858 5 similar to F-box and WD-40 domain protein 2 LOC345462 5q35.3 similar to hypothetical protein 9630041N07 ZNF354C 5q35.3 zinc finger protein 354C LOC345463 5q35.3 similar to UNR protein ADAMTS2 5q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 LOC391859 5 similar to Tb-291 membrane associated protein LOC389351 5 similar to 6-pyruvoyl-tetrahydropterin synthase RUFY1 5q35.3 RUN and FYVE domain containing 1 HNRPH1 5q353 heterogeneous nuclear ribonucleoprotein H1 (H) LOC202404 5q35.3 hypothetical LOC202404 LOC285679 5q35.3 hypothetical protein LOC285679 LOC389352 5 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) CANX 5q35 calnexin MAML1 5q35 mastermind-like 1 (Drosophila) FLJ12121 5q35.3 hypothetical protein FLJ12121 LTC4S 5q35 leukotriene C4 synthase MGAT4B 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130 LOC255426 LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2 KIAA1194 5q35.3 Homo sapiens KIAA1194 (KIAA1194), mRNA. SCGB3A1 5q35-qter secretoglobin, family 3A, member 1 FLT4 5q35.3 fms-related tyrosine kinase 4 LOC134082 5q35.3 similar to seven transmembrane helix receptor LOC134083 5q35.3 similar to Olfactory receptor 2Y1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2124 63.2 548 - Yoshida
    - splicing 2891 64.8 563 - Yoshida
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG9384
    Homologene
    FAMILY
  • glycosyltransferase 54 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • catalyzing the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4 GlcNAc-beta-1,4-GlcNAc-beta-1-Asn
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS