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FLASH GENE
Symbol MGAT4A contributors: npt - updated : 29-04-2006
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
HGNC id 7047
Location 2q12      Physical location : 99.235.570 - 99.347.589
Synonym name
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A
  • GlcNAc-T IVa
  • UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa
  • Synonym symbol(s) GNT-IV, GNT-IVA
    EC.number 2.4.1.145
    DNA
    TYPE functioning gene
    STRUCTURE 112.02 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391409 2 hypothetical gene supported by NM_138800 LOC375247 2q11.2 hypothetical LOC375247 DKFZp434N062 2q11.2 hypothetical protein DKFZp434N062 UNQ2430 2q11.2 ankyrin-related KIAA1641 2q11.2 KIAA1641 protein UBE3AP1 2q11.1 ubiquitin protein ligase E3A pseudogene 1 LOC389008 2 similar to KIAA1641 protein LOC151320 2q11.2 similar to autoantigen NOR-90 COX5B 2cen-q13 cytochrome c oxidase subunit Vb ACTR1B 2q11.1-q11.2 ARP1 actin-related protein 1 homolog B, centractin beta (yeast) RNU4P2 2q11.2 RNA, U4 small nuclear pseudogene 2 (U4/14) LOC130639 2q11.2 hypothetical LOC130639 ZAP70 2q12 zeta-chain (TCR) associated protein kinase 70kDa RW1 2q11.2 RW1 protein MGC26733 2q11.2 hypothetical protein MGC26733 CNGA3 2q11.2 cyclic nucleotide gated channel alpha 3 INPP4A 2q11.2 inositol polyphosphate-4-phosphatase, type I, 107kDa GMH1 MGAT4A 2q12 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A LOC343990 2q11.2 hypothetical LOC343990 TSGA10 2q11.2 testis specific, 10 MGC29762 LIPT1 2q11.2 testis specific, 10 LOC129531 2q11.2 hypothetical protein BC018453 MRPL30 2q11.2 mitochondrial ribosomal protein L30 LYG2 2q11.2 lysozyme-like LOC129530 2q11.2 hypothetical protein LOC129530 APACD 2q11.2 ATP binding protein associated with cell differentiation IF2 2p11.1-q11.1 ATP binding protein associated with cell differentiation REV1L 2q11.1-q11.2 REV1-like (yeast) LAF4 2q11.2-q12 lymphoid nuclear protein related to AF4 LOC389009 2 LOC389009
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 8382 61.5 535 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three potential N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to bovine GnT-IV
    homolog to Drosophila CG9384
    Homologene
    FAMILY
  • glycosyltransferase 54 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • catalyzing the transfer of GlcNAc from UDP-GlcNAc in beta-1,4 linkage to alpha-1,3-D-mannoside on GlcNAc-beta-1,2-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS