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FLASH GENE
Symbol MGAT3 contributors: mct - updated : 03-05-2008
HGNC name mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
HGNC id 7046
Location 22q13.1      Physical location : 39.853.324 - 39.888.197
Synonym name
  • GlcNAc-T III
  • N-acetylglucosaminyltransferase III
  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
  • Synonym symbol(s) NAGT3, GNT3, GGNT3, RP5-1104E15.2, FLJ43371, GNT-III, GNT3, MGC141943, MGC142278
    EC.number 2.4.1.144
    DNA
    TYPE functioning gene
    STRUCTURE 34.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map see SYNGR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5102 - 533 - Fiala (2007)
    - - 4987 - 533 - Fiala (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • short N cytoplasmic domain
  • a transmembrane domain,
  • a neck region
  • a long C terminal tail with the catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Mgat3
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in biosynthesis of complex Asn-linked (N) glycans
  • involved in modification of N-glycan of integrin (inhibits its ligand binding ability, subsequently leading to the down-regulation of integrin-mediated signaling)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CDH1, MGAT5 (regulatory mechanism between CDH1, MGAT3 and MGAT5 by enzymatic competition which could underlie a possible novel signaling pathway in carcinogenesis) (Pinho 2009)
  • cell & other
    REGULATION
    Other regulated by CDH1 (regulates MGAT3 gene transcription and leads to a significant up-regulation of its mRNA transcription levels) (Pinho 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS