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FLASH GENE
Symbol MGAT1 last update : 13-06-2008
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
HGNC id 7044
Location 5q35
Synonym name N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
Synonym symbol(s) NAGT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GGNT1
EC.number 2.4.1.101
DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 12.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure housekeeping gene
MAPPING cloned Y linked   status confirmed
Physical map
SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130 LOC255426 LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2 KIAA1194 5q35.3 Homo sapiens KIAA1194 (KIAA1194), mRNA. SCGB3A1 5q35-qter secretoglobin, family 3A, member 1 FLT4 5q35.3 fms-related tyrosine kinase 4 LOC134082 5q35.3 similar to seven transmembrane helix receptor LOC134083 5q35.3 similar to Olfactory receptor 2Y1 MGAT1 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase FLJ21458 5q35.3 hypothetical protein FLJ21458 LOC391861 5 similar to cAMP-regulated phosphoprotein 19 (ARPP-19) BTNL3 5q35 butyrophilin-like 3 FLJ32535 5q35.3 butyrophilin 3 FOXO1B 5q35.2-q35.3 forkhead box O1B LOC340050 5q35.3 similar to hypothetical protein LOC340052 5q35.3 similar to seven transmembrane helix receptor LOC285659 5q35.3 similar to Olfactory receptor 2V3 LOC389353 5 LOC389353 TRIM7 5q35.3 tripartite motif-containing 7 TRIM41 5q35.3 tripartite motif-containing 41 GNB2L1 5q35.3-qter guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 FLJ23053 5q35.3 hypothetical protein FLJ23053 TRIM52 5q35.3 tripartite motif-containing 52 LOC389354 5 hypothetical gene supported by AL137733 LOC389355 5 similar to bA476I15.3 (novel protein similar to septin) LOC391862 5 similar to Olfactory receptor 4F3
RNA
TRANSCRIPTS type messenger
text All variants encode the same protein
identificationnb exonstypebpproduct
kDaAAspecific expressionauthor
variant 2 - - 2937
50.8 445 - Saribas (2007)
-
variant 1 - - 3181
50.8 445 - Saribas (2007)
-
variant 3 - - 3095
50.8 445 - Saribas (2007)
-
variant 4 - - 2658
50.8 445 - Saribas (2007)
-
variant 5 - - 2869
50.8 445 - Saribas (2007)
-
EXPRESSION / SUBCELLULAR LOCALIZATION
EXPRESSION (based on citations) ubiquitous
constitutive of
   expressed in
organ(s)
SystemOrgan 1organ 2organ 3organ 4level
Digestivemouth   highly
Lymphoid/Immunespleen   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,Golgi ,lumen,membrane
text type II membrane protein
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies
 
intraspecies
 
Homologene
FAMILY
  • glycosyltransferase 13 family
    • CATEGORY enzyme
    basic FUNCTION
  • involved in biosynthesis of complex Asn-linked (N) glycans
  • monoacylglycerol acyltransferase, catalyzing the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids
  • in the intestine, plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
  • controls complex and hybrid N-glycan synthesis
    • implicated in a
    process
    cellular process
    physiological development
    text essential for normal embryogenesis, symetry breaking
    pathway
    metabolism carbohydrate
    signaling
    a component
    structural
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Therapy target
    animal or cellular model mutant Mgt1-/- have impaired neural tube formation,vascularizations and left-right (L/R asymetry)