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FLASH GENE
Symbol MGAT1 contributors: mct/npt - updated : 01-08-2012
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
HGNC id 7044
Location 5q35.3      Physical location : 180.217.542 - 180.237.137
Synonym name N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
Synonym symbol(s) NAGT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GGNT1
EC.number 2.4.1.101
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 19.60 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure housekeeping gene
MAPPING cloned Y linked   status confirmed
Physical map
SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130 LOC255426 LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2 KIAA1194 5q35.3 Homo sapiens KIAA1194 (KIAA1194), mRNA. SCGB3A1 5q35-qter secretoglobin, family 3A, member 1 FLT4 5q35.3 fms-related tyrosine kinase 4 LOC134082 5q35.3 similar to seven transmembrane helix receptor LOC134083 5q35.3 similar to Olfactory receptor 2Y1 MGAT1 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase FLJ21458 5q35.3 hypothetical protein FLJ21458 LOC391861 5 similar to cAMP-regulated phosphoprotein 19 (ARPP-19) BTNL3 5q35 butyrophilin-like 3 FLJ32535 5q35.3 butyrophilin 3 FOXO1B 5q35.2-q35.3 forkhead box O1B LOC340050 5q35.3 similar to hypothetical protein LOC340052 5q35.3 similar to seven transmembrane helix receptor LOC285659 5q35.3 similar to Olfactory receptor 2V3 LOC389353 5 LOC389353 TRIM7 5q35.3 tripartite motif-containing 7 TRIM41 5q35.3 tripartite motif-containing 41 GNB2L1 5q35.3-qter guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 FLJ23053 5q35.3 hypothetical protein FLJ23053 TRIM52 5q35.3 tripartite motif-containing 52 LOC389354 5 hypothetical gene supported by AL137733 LOC389355 5 similar to bA476I15.3 (novel protein similar to septin) LOC391862 5 similar to Olfactory receptor 4F3
RNA
TRANSCRIPTS type messenger
text All variants encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2937 50.8 445 - 2007 17716624
3 - 3181 50.8 445 - 2007 17716624
3 - 3095 50.8 445 - 2007 17716624
2 - 2658 50.8 445 - 2007 17716624
2 - 2869 50.8 445 - 2007 17716624
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunespleen   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • glycosyltransferase 13 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • involved in biosynthesis of complex Asn-linked (N) glycans
  • monoacylglycerol acyltransferase, catalyzing the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids
  • in the intestine, plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
  • controls complex and hybrid N-glycan synthesis
  • involved in dietary fat absorption
  • MGAT1-dependent N-glycans are essential for the normal development
  • increased PPARG and MGAT1 activity during a high-fat diet (HFD) plays a major role in developing hepatic steatosis by regulating fatty acid transport and the triglyceride (TG) incorporation pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text essential for normal embryogenesis, symetry breaking
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPARG directly regulates the MGAT1 promoter activity
  • directly regulated by PPARG and plays a role in regulating the pathway leading to incorporation of fatty acid into TG
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    inactivation of the MGAT1 gene in oocytes impairs oogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    metabolismlipid 
    inhibition of PPARG-induced MGAT1 for the alternative TG synthesis pathway would be one of the excellent therapeutic targets for hepatic steatosis
    ANIMAL & CELL MODELS
  • mutant Mgt1-/- have impaired neural tube formation,vascularizations and left-right (L/R asymetry)
  • null mutations in Drosophila Mgat1 are viable but exhibit defects in locomotion, brain abnormalities, and a severely reduced life span