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FLASH GENE
Symbol MFSD6 contributors: SGE - updated : 29-07-2010
HGNC name major facilitator superfamily domain containing 6
HGNC id 24711
Location 2q32.2      Physical location : 191.273.080 - 191.367.041
Synonym name
  • macrophage MHC class I receptor 2 homolog
  • major facilitator superfamily domain-containing protein 6
  • macrophage MHC receptor 2
  • Synonym symbol(s) FLJ20160, MMR2, hMMR2
    DNA
    TYPE functioning gene
    STRUCTURE 93.96 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4797 - 791 - Shimizu (2010)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal extracellular domain
  • a transmembrane domain
  • a C-terminal cytoplasmic domain
  • in extracellular domain : four N-glycosylation sites and a predicted HLA binding region
  • in the cytoplasmic domain : two immunoreceptor tyrosine-based activation motifs (ITAMs) ; several putative phosphorylation sites
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Mfsd6 (89.8pc)
    homolog to rattus Mfsd6 (88.2pc)
    Homologene
    FAMILY
  • major facilitator superfamily
  • MFSD6 family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transmembrane transport
  • may be a novel receptor for HLA-B62 (shimizu 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically binding pentameric HLA-B62 molecules (Shimizu 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS