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FLASH GENE
Symbol MFNG contributors: npt - updated : 12-05-2007
HGNC name MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
HGNC id 7038
Location 22q13.1      Physical location : 37.865.100 - 37.882.478
Synonym name manic fringe homolog (Drosophila)
EC.number 2.4.1.222
DNA
TYPE functioning gene
STRUCTURE 17.28 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MPST 22q13.1 mercaptopyruvate sulfurtransferase FLJ12242 22q13.1 hypothetical protein FLJ12242 TMPRSS6 22q13.1 transmembrane serine protease 6 IL2RB 22q13.1 interleukin 2 receptor, beta C1QTNF6 22q13.1 C1q and tumor necrosis factor related protein 6 SSTR3 22q13.1 somatostatin receptor 3 RAC2 22q13.1 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) PSCD4 22q13.1 pleckstrin homology, Sec7 and coiled-coil domains 4 KIAA1904 22q13.1 KIAA1904 protein MFNG 22q13.1 manic fringe homolog (Drosophila) CARD10 22q13 caspase recruitment domain family, member 10 CDC42EP1 22q13.1 CDC42 effector protein (Rho GTPase binding) 1 LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP LGALS1 22q13.1 lectin, galactoside-binding, soluble, 1 (galectin 1) MGC3731 22q13.1 hypothetical protein MGC3731 HRIHFB2122 22q13.1 hypothetical protein MGC3731 H1F0 22q13.1 H1 histone family, member 0 GCAT 22q13.1 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2040 36.2 321 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila manic fringe
homolog to murine Mfng
Homologene
FAMILY
  • fringe gene family
  • glycosyltransferase 31 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • essential mediator of somite segmentation and patterning
  • putative regulator of developmental processes through alternative regulation of the sensitivity of NOTCH receptor genes for their specific ligands (delta, Jagged 2)
  • glycosyl transferase with N-acetylglucosaminyltransferase activity with elongation of 0-linked fucose residues,on side chains located at some of the EGF-repeats of NOTCH*
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    Notch pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS