Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MFGE8 contributors: mct - updated : 12-07-2014
HGNC name milk fat globule-EGF factor 8 protein
HGNC id 7036
Location 15q26.1      Physical location : 89.441.915 - 89.456.663
Genatlas name lactadherin
Synonym name lactadherin precursor, medin
Synonym symbol(s) HMFG, BA46, EDIL1, SED1
DNA
TYPE functioning gene
STRUCTURE 14.75 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2005 43.12 387 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Cardiovascularvesselsaorta   
Digestiveintestinesmall intestine  highly
Reproductivefemale systembreastmammary gland highly
 male systemmale genital tractepididymis highly Homo sapiens
Respiratoryrespiratory tractbronchus  highly Homo sapiens
Skeleton      Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretoryalveolar epithelium   Homo sapiens
Epithelialsecretoryglandularendocrine 
Muscularsmooth    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast Homo sapiens
cell lineage
cell lines breast carcinoma cell lines
fluid/secretion milk
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two epidermal growth factor-like repeat domains linked to two 142 residue tandem repeated C-terminal
  • two discoidin/Factor V/VIII C domains, shown to bind phosphatidylserine (PS) on apoptotic cells
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine mammary protein MFG-E8
    intraspecies homolog to F5,F8C,PROC
    Homologene
    FAMILY
    CATEGORY adhesion , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in phospholipid binding and having an important regulatory function in the aorta
  • playing a crucial role in VEGF-dependent neovascularization and acting as an important target for the modulation of neovascularization
  • participating in diverse cellular interactions, such as sperm binding to the egg coat and macrophage recognition of apoptotic lymphocytes
  • having an unexpected obligatory role during mammary gland development
  • modulates inflammation by binding and targeting apoptotic cells for clearance through an integrin-dependent pathway
  • facilitates epididymal cell adhesion, and that its loss leads to breakdown of the epididymal epithelium and consequent development of spermatic granulomas
  • implicated in enhancement of vascular endothelial growth factor-dependent angiogenesis
  • implicated in pericyte/pericyte precursor function
  • key role of MFGE8 release from apoptotic endothelial cells in macrophage reprogramming, demonstrating the importance of the apoptotic microenvironment in anti-inflammatory macrophage responses
  • possible role in endometrial reorganization during the receptive phase and in events related to normal pregnancy in mammals
  • specifically suppresses the molecular pathway that induces smooth muscle hypercontractility in the cytokine-rich environment of allergic airway disease
  • key factor involved in the phagocytosis of apoptotic cells
  • plays an important role in phagocytosis, and possibly serves as an essential signal molecule for microglial cells
  • MFGE8-dependent promotion of apoptotic cell clearance is a novel anti-inflammatory facet of glucocorticoids (GCs) treatment
  • plays a multifunctional role in attenuating inflammation and improving prognosis, healing wound and remodeling arterial and enhancing tumorigenicity and cancer metastasis
  • promotes the absorption of dietary triglycerides and the cellular uptake of fatty acid
  • role in regulating the absorption and storage of dietary fats, as well as in the development of obesity and its complications
  • is a novel homeostatic regulator of osteoclasts
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MFGE8 binding to integrin receptors on airway smooth muscle (ASM) opposes the effect of allergic inflammation on RHOA activity and identify a pathway for specific inhibition of ASM hypercontractility in asthma
  • opposes enhanced bronchial smooth muscle contraction induced by IL13
  • TNF up-regulates endometrial epithelial cell migration and MFGE8 production, which are critical steps required for the endometrial changes during menstrual cycle as well as during embryonic attachment and invasion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    n airways of patients with asthma
    constitutional        
    MFGE8-null epididymal fluid is both hypo-osmotic and alkaline, relative to wildtype epididymal fluid
    Susceptibility to systemic lupus erythematosus(SLE)
    Variant & Polymorphism other intronic mutation in the human MFGE8 gene can lead to the development of SLE
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneothers
    target to treat periodontitis and perhaps other immunological disorders associated with inflammatory bone loss
    cancerreproductivebreast
    use of MFGE8-blocking antibodies as new anti-cancer therapeutics in subgroups of triple-negative breast carcinoma patients.
    cancerreproductiveovary
    use of MFGE8-blocking antibodies as new anti-cancer therapeutics in subgroups of ovarian carcinoma
    allergyasthm 
    target for treatments having a potentially high impact given the central role of ASM in bronchospasm
    ANIMAL & CELL MODELS
  • SED1-null glands show severely reduced branching from epithelial ducts and from terminal end buds, which are thin and poorly developed
  • Mfge8-deficient mice are protected from diet-induced obesity, steatohepatitis and insulin resistance