basic FUNCTION
| involved in phospholipid binding and having an important regulatory function in the aorta |
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playing a crucial role in VEGF-dependent neovascularization and acting as an important target for the modulation of neovascularization |
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participating in diverse cellular interactions, such as sperm binding to the egg coat and macrophage recognition of apoptotic lymphocytes |
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having an unexpected obligatory role during mammary gland development |
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modulates inflammation by binding and targeting apoptotic cells for clearance through an integrin-dependent pathway |
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facilitates epididymal cell adhesion, and that its loss leads to breakdown of the epididymal epithelium and consequent development of spermatic granulomas |
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implicated in enhancement of vascular endothelial growth factor-dependent angiogenesis |
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implicated in pericyte/pericyte precursor function |
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key role of MFGE8 release from apoptotic endothelial cells in macrophage reprogramming, demonstrating the importance of the apoptotic microenvironment in anti-inflammatory macrophage responses |
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possible role in endometrial reorganization during the receptive phase and in events related to normal pregnancy in mammals |
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specifically suppresses the molecular pathway that induces smooth muscle hypercontractility in the cytokine-rich environment of allergic airway disease |
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key factor involved in the phagocytosis of apoptotic cells |
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plays an important role in phagocytosis, and possibly serves as an essential signal molecule for microglial cells |
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MFGE8-dependent promotion of apoptotic cell clearance is a novel anti-inflammatory facet of glucocorticoids (GCs) treatment |
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plays a multifunctional role in attenuating inflammation and improving prognosis, healing wound and remodeling arterial and enhancing tumorigenicity and cancer metastasis |
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promotes the absorption of dietary triglycerides and the cellular uptake of fatty acid |
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role in regulating the absorption and storage of dietary fats, as well as in the development of obesity and its complications |
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is a novel homeostatic regulator of osteoclasts |