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FLASH GENE
Symbol MFF contributors: mct - updated : 08-06-2016
HGNC name mitochondrial fission factor
HGNC id 24858
Location 2q36.3      Physical location : 228.192.227 - 228.222.547
Synonym name
  • GL004 protein
  • hypothetical protein LOC56947
  • chromosome 2 open reading frame 33
    • Synonym symbol(s) GL004, AD030, AD033, DKFZp666J168, MGC110913, C2orf33
    DNA
    TYPE functioning gene
    STRUCTURE 30.32 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2032 38 342 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY tango11 family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • MFF and FIS1 are both tail anchored in the mitochondrial outer membrane
    • basic FUNCTION
  • novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes
  • mitochondrial fission requires the dynamin-like protein DNM1L that is recruited to the mitochondrial surface, possibly through the membrane-anchored protein FIS1 or MFF
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitochondrial fission proteins DNM1L and MFF negatively regulate MARCH5 activity toward MIEF2 and MCL1
  • SENP3-mediated deSUMOylation of DNM1L facilitates interaction with MFF to promote cell death
  • DNM1L receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa (MIEF1 and MIEF2) and mitochondrial fission factor (MFF)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS