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FLASH GENE
Symbol MFAP4 contributors: - updated : 22-11-2006
HGNC name microfibrillar-associated protein 4
HGNC id 7035
Location 17p11.2      Physical location : 19.286.756 - 19.290.493
Synonym name microfibril-associated glycoprotein 4
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC339244 17p11.2 keratin pseudogene LOC252968 17p11.2 karyopherin (importin) beta 2 pseudogene LOC147158 17p11.2 lectin, galactoside-binding, soluble, 9 (galectin 9) pseudogene LOC201288 17p11.2 nitric oxide synthase 2A (inducible, hepatocytes) pseudogene LOC220594 17p11.2 TL132 protein FLJ11800 17p11.2 hypothetical protein FLJ11800 LOC252840 17p11.1 signal recognition particle 68kD pseudogene LOC201287 17p11.2 KIAA0565 related gene FLJ36492 17p11.2 hypothetical protein FLJ36492 FLJ40244 17p11.2 hypothetical protein FLJ40244 LOC388345 17 similar to poly(A) binding protein interacting protein 1 isoform 1; polyadenylate binding protein-interacting protein 1; PABC1-interacting protein 1 FOXO3B 17p11 forkhead box O3B LOC390771 17 similar to Ubiquitin-conjugating enzyme E2-24 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2-EPF5) LOC147166 17p11.2 similar to Tripartite motif protein 16 (Estrogen-responsive B box protein) FAM18B 17p11.2 family with sequence similarity 18, member B LOC388346 17 similar to hypothetical protein FLJ36492 PRPSAP2 17p11.2 phosphoribosyl pyrophosphate synthetase-associated protein 2 FLJ25217 GRAP 17p11.2 GRB2-related adaptor protein LOC339249 17p11.2 hypothetical LOC339249 LOC388347 17 hypothetical gene supported by BC058012 LOC390772 17 similar to GRB2-related adaptor protein FLJ22659 17p11.2 hypothetical protein FLJ22659 LOC388348 17 LOC388348 EPN2 17p11.2 epsin 2 EPPB9 17p11.2 B9 protein MAPK7 17p11.2 mitogen-activated protein kinase 7 MFAP4 17p11.2 microfibrillar-associated protein 4 ZNF179 17p11.2 zinc finger protein 179 LOC125208 17p11 ribosomal protein S2 pseudogene LOC390773 17 similar to Rpl17 protein FLJ10847 17p11.2 hypothetical protein FLJ10847 LOC388350 17 LOC388350 LOC388351 17 similar to hypothetical protein FLJ10847 ALDH3A2 17p11.2 aldehyde dehydrogenase 3 family, member A2 FLJ31196 17p11.2 hypothetical protein FLJ31196 ALDH3A1 17p11.2 aldehyde dehydrogenase 3 family, memberA1 ULK2 17p11.2 unc-51-like kinase 2 (C. elegans) AKAP10 17p11.2 a kinase (PRKA) anchor protein 10 HCMOGT-1 17p11.2 sperm antigen HCMOGT-1
regionally located between SMS-REPM and SMS-REPP
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vesselsaorta   
Digestivestomach   highly
Lymphoid/Immunethymus   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Membraneadvantitia   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RGD in the N terminal domain
  • a fibrinogen-like domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to bovine microfibril-associated protein
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text microfibrils elastin-associated in the extracellular matrix
    basic FUNCTION Ca2+ dependent cell adhesion or cell/cell interactions
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith-Magenis syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS