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FLASH GENE
Symbol MFAP4 contributors: - updated : 22-11-2006
HGNC name microfibrillar-associated protein 4
HGNC id 7035
Location 17p11.2      Physical location : 19.286.756 - 19.290.493
Synonym name microfibril-associated glycoprotein 4
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located between SMS-REPM and SMS-REPP
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vesselsaorta   
Digestivestomach   highly
Lymphoid/Immunethymus   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Membraneadvantitia   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RGD in the N terminal domain
  • a fibrinogen-like domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to bovine microfibril-associated protein
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text microfibrils elastin-associated in the extracellular matrix
    basic FUNCTION Ca2+ dependent cell adhesion or cell/cell interactions
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith-Magenis syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS