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FLASH GENE
Symbol MFAP3 contributors: - updated : 22-11-2006
HGNC name microfibrillar-associated protein 3
HGNC id 7034
Location 5q32      Physical location : 153.418.518 - 153.437.014
Synonym symbol(s) AAAP-40, MAGP-3
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421 SLC36A1 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1 FAT2 5q31-q32 FAT tumor suppressor homolog 2 (Drosophila) SPARC 5q32 secreted protein, acidic, cysteine-rich (osteonectin) ATOX1 5q32-q33 ATX1 antioxidant protein 1 homolog (yeast) LOC389338 5 LOC389338 G3BP 5q33.3 LOC389338 GLRA1 5q32 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1 NMU2R 5q33.2 neuromedin U receptor 2 GRIA1 5q33 glutamate receptor, ionotropic, AMPA 1 C5orf3 5q31-q32 chromosome 5 open reading frame 3 MFAP3 5q32 microfibrillar-associated protein 3 GALNT10 5q33.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) FLJ11526 5q33.2 hypothetical protein FLJ11526 HAND1 5q32 heart and neural crest derivatives expressed 1 LOC389339 5 LOC389339 LARP 5q33.2 likely ortholog of mouse la related protein C5orf4 5q31-q32 chromosome 5 open reading frame 4 CNOT8 5q31-q33 CCR4-NOT transcription complex, subunit 8 GEMIN5 5q33.3 gem (nuclear organelle) associated protein 5 MRPL22 5q33.1-q33.3 mitochondrial ribosomal protein L22 LOC285643 5q33.2 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) LOC391842 5 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC389340 5 LOC389340 SGCD 5q33 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineadrenal gland   highly
 parathyroid   highly
 thyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fibrinogen and vitronectin-like domains,
  • a possible Ca2+ binding site
  • a Ig-like C2-type (immunoglobulin-like) domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix, cuticule and basement membrane
    basic FUNCTION component of the elastin-associated microfibrils
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component of microfibrils of elastin-associated in the extracellular matrix
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS