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FLASH GENE
Symbol MEX3D contributors: - updated : 23-08-2007
HGNC name mex-3 homolog D (C. elegans)
HGNC id 16734
Location 19p13.3      Physical location : 1.554.668 - 1.568.057
Synonym name
  • bcl-2 ARE RNA binding protein
  • ring finger and KH domain containing 1
  • Synonym symbol(s) KIAA2031, TINO, RNF193, RKHD1, MEX3, MEX-3D
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2676 66 666 - Buchet-Poyau
  • 3 exons
  • - splicing 2863 64 651 - Donnini
  • 2 exons
  • including an alternate segment in the 3' coding region compared to variant 1
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
    Endocrineneuroendocrinepituitary  highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two KH domains
  • a RING-type zinc finger
  • conjugated PhosphoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to chimpanzee RKHD1 (99.8 pc)
    homolog to rattus Rkhd1 (84.8 pc)
    homolog to murine Rkhd1 (87.5 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominantly expressed in the cytoplasm
  • shuttling between the cytoplasm and the nucleus through the CRM1 export pathway
  • basic FUNCTION
  • endowed with a putative E3 ubiquitin-protein ligase activity
  • playing a negative regulatory action on BCL-2 gene expression at the posttranscriptional level
  • may be involved in post-transcriptional regulatory mechanisms
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA binding through its KH domains
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with BCL2 ARE(AU-rich element)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS