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FLASH GENE
Symbol MEX3C contributors: mct - updated : 17-12-2014
HGNC name mex-3 homolog C (C. elegans)
HGNC id 28040
Location 18q21.2      Physical location : 48.700.921 - 48.724.051
Synonym name
  • RING finger protein 194
  • RNA-binding protein MEX3C
  • ring finger and KH domain containing 2
  • RING finger and KH domain-containing protein 2
  • Synonym symbol(s) RKHD2, BM-013, MEX-3C, RNF194,
    DNA
    TYPE functioning gene
    STRUCTURE 23.13 kb     2 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4168 - 659 - 2012 22357625
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Endocrineparathyroid   highly
     thyroid   predominantly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly Homo sapiens
    Reproductivefemale systemovary  moderately
     male systemtestis  highly Homo sapiens
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal nuclear export signal (NES)
  • two ribonucleoprotein K homology (KH) domains
  • a C-terminal RING-type finger domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to C -elegans muscle excess 3 (MEX-3)
    homolog to rattus Rkhd2 (98.8 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • shuttling between the nucleus and cytoplasm in an NES-dependent manner
  • predominantly expressed in the cytoplasm
  • shuttles between the cytoplasm and the nucleus through the CRM1 export pathway
  • basic FUNCTION
  • may be involved in post-transcriptional regulatory mechanisms
  • plays an important role in enhancing the translation of IGF1 mRNA
  • RNA-binding ubiquitin E3 ligase, responsible for the post-transcriptional, allotype-specific regulation of MHC-I
  • regulates adiposity through controlling physical activity, and neuronal MEX3C expression could play an important role in this process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding via the KH domains
    small molecule metal binding,
  • Zn2+
  • protein
  • MEX3A and MEX3B, but not MEX3C, colocalize with both the DCP1A decapping factor and Argonaute (AGO1) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover
  • necessary for normal postnatal growth and enhances the expression of local bone IGF1 expression
  • is an E3 ubiquitin ligase that modifies DDX58 in stress granules and plays a critical role in eliciting antiviral immune responses
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to hypertension
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mex3c mutation in mice causes growth retardation and reduced adiposity