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FLASH GENE
Symbol METTL8 contributors: mct - updated : 05-11-2019
HGNC name methyltransferase like 8
HGNC id 25856
Location 2q31.1      Physical location : 172.173.914 - 172.291.312
Synonym name
  • tension-induced/inhibited protein
  • Synonym symbol(s) TIP, FLJ13334, FLJ13984, FLJ31054, FLJ42098, FLJ77788
    DNA
    TYPE functioning gene
    STRUCTURE 119.06 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 9809 - 407 - 2017 28655767
    8 - 9499 - 246 - 2017 28655767
    9 - 9606 - 362 - 2017 28655767
    11 - 9885 - 455 - 2017 28655767
    9 - 9615 - 357 - 2017 28655767
    10 - 9770 - 407 - 2017 28655767
    9 - 9632 - 241 - 2017 28655767
    10 - 9787 - 291 - 2017 28655767
    11 - 9894 - 407 - 2017 28655767
    11 - 9964 - 407 - 2017 28655767
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SANT (switching-defective protein 3, adaptor 2, nuclear receptor corepressor, and transcription factor IIIB) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • role in myogenic versus adipogenic differentiation
  • METTL2A and METTL6 contribute 3-methylcytidine (m3C) in specific tRNAs and METTL8 only contributes m3C to mRNA
  • METTL8 is dispensable for pluripotency but affects embryonic stem cells (ESCs) differentiation
  • METTL8) was identified to be the writer enzyme of N3-methylcytidine (m3C)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • having a SANT-dependent, EP300-mediated histone acetyltransferase (HAT) activity
  • STAT3 target METTL8, regulates likely ESC differentiation via JNK signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS