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FLASH GENE
Symbol METTL5 contributors: mct - updated : 04-11-2019
HGNC name methyltransferase like 5
HGNC id 25006
Corresponding disease
MCPH27 microcephaly 27
Location 2q31.1      Physical location : 170.668.269 - 170.681.353
Synonym name HSPC133 protein
Synonym symbol(s) HSPC133, FLJ10459
DNA
TYPE functioning gene
STRUCTURE 13.17 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 813 - 209 - 2019 31564433
8 - 899 - 209 - 2019 31564433
7 - 1001 - 209 - 2019 31564433
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta   
Nervousbraindiencephalonhypothalamus  
 brainlimbic systemhippocampus   Homo sapiensAdult
 brainlimbic systemhippocampus   Homo sapiensFetal
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text posterior rhombomeres, trabecular meshwork, fetal eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY methyltransferase-like protein family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
text
  • METTL5 and ZCCHC4 localize to the nucleoli and nucleus, respectively
  • enriched in the nucleus and synapses of the hippocampal neurons
  • basic FUNCTION
  • having S-adenosylmethionine-dependent methyltransferase activity
  • METTL5 works in close association with TRMT112 and is stabilized by it
  • METTL5 and ZCCHC4 are not essential to growth or ribosome biogenesis, and METTL5 gains metabolic stability by associating with human TRMT112
  • METTL5 decorates the 18S rRNA with one N6-methyladenosine (m6A) and ZCCHC4 installs another m6A on 28S rRNA
  • essential role of METTL5 in brain development and neuronal function
  • might have a global epigenetic regulatory role in the brain as well as a synapse-dependent role
  • participates in the epigenetic regulation of DNA/RNA in the neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA interaction
    RNA binding
    small molecule
    protein
  • METTL5–TRMT112 acts by extruding the adenosine to be modified from a double-stranded nucleic acid
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH27
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS