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FLASH GENE
Symbol METTL4 contributors: mct - updated : 06-11-2019
HGNC name methyltransferase like 4
HGNC id 24726
Location 18p11.32      Physical location : 2.537.524 - 2.571.489
Synonym symbol(s) HsT661, FLJ23017, MGC117235
EC.number 2.1.1.-/2.1.1.72
DNA
TYPE functioning gene
STRUCTURE 33.98 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3592 - 419 - 2019 30982744
9 - 3684 - 472 - 2019 30982744
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC316731
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • methyltransferase activity
  • enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), regulates the pace of the circadian clock
  • DNMT3A and METTL4 as the most relevant potential regulators of melanoma growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to dysesthesia
    Variant & Polymorphism other
  • rs2677879 polymorphism located in the METTL4 gene assocated with dysesthesia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS