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FLASH GENE
Symbol METTL3 contributors: - updated : 27-04-2004
HGNC name methyltransferase like 3
HGNC id 17563
Location 14q11.1      Physical location : 21.966.282 - 21.979.457
Synonym symbol(s) 2310024F18Rik, Spo8, M6A
EC.number 2.1.1.62
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     0 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
 thymus   lowly
Digestiveintestinesmall intestine  lowly
Endocrinepancreas   lowly
Reproductivefemale systemovary  lowly
 male systemprostate  lowly
 male systemtestis  lowly
Respiratorylung   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one MT-A70 domain
HOMOLOGY
Homologene
FAMILY methyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
basic FUNCTION
  • methylates adenosine residues of some mRNAs
  • may play a role in the efficiencey of mRNA splicing, transport or translation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS