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FLASH GENE

Symbol

METTL23

contributors: mct - updated : 26-09-2014

HGNC name	methyltransferase like 23
HGNC id	26988

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRT44 mental retardation, autosomal recessive 44
Location	17q25.1      Physical location : -
Synonym symbol(s)	C17orf95, MRT44

DNA

TYPE	functioning gene
STRUCTURE	7.82 kb

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001206987 4 - 1226 NP_001193916 - 123 - 2013 23349634 NM_001206983 5 - 1187 NP_001193912 - 190 - 2013 23349634 NM_001080510 5 - 1152 NP_001073979 - 190 - 2013 23349634 NM_001206986 4 - 1082 NP_001193915 - 123 - 2013 23349634 NM_001206985 5 - 1047 NP_001193914 - 123 - 2013 23349634 NM_001206984 5 - 853 NP_001193913 - 190 - 2013 23349634

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	is essential for human cognition
	strongly predicted to function as an S-adenosyl-methionine (SAM)-dependent methyltransferase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	METTL23 interacted with GABPA (importance of METTL23 as a regulator of GABPA function)
	strong association with heat shock proteins, which suggests that these may act as a putative substrate for methylation by METTL23

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRT44

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS