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FLASH GENE
Symbol METTL21A contributors: mct - updated : 14-01-2021
HGNC name methyltransferase like 21A
HGNC id 30476
Location 2q33.3      Physical location : -
Synonym name
  • hepatocellular carcinoma-associated antigen HCA557b
  • hypothetical protein LOC151194
  • family with sequence similarity 119, member A
  • Synonym symbol(s) MGC45373, LOC151194, HCA557b, FAM119A, HSPA-KMT
    EC.number 2.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 45.42 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4805 - 218 - 2013 23921388
    4 - 4748 - 218 - 2013 23921388
    3 - 1977 - 127 - 2013 23921388
    4 - 2191 - 90 - 2013 23921388
    4 - 1944 - 90 - 2013 23921388
    5 - 1138 - 127 - 2013 23921388
    4 - 1933 - 127 - 2013 23921388
    4 - 2147 - 90 - 2013 23921388
    4 - 1749 - 127 - 2013 23921388
    4 - 1093 - 127 - 2013 23921388
    4 - 4951 - 218 - 2013 23921388
    5 - 4819 - 236 - 2013 23921388
    4 - 4748 - 218 - 2013 23921388
    4 - 2649 - 218 - 2013 23921388
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine 2310038H17Rik
    Homologene
    FAMILY
  • FAM119 family
  • esophageal carcinoma SEREX antigen ECSA family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • enzyme responsible for trimethylation of a conserved lysine residue found in several human Hsp70 (HSPA) proteins
  • with METTL21A, EEF1AKMT3, methylates chaperones involved in the etiology of both myopathy and inclusion body myositis with Paget's disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exclusively methylates 70-kDa proteins in mammalian protein extracts, demonstrating that it is a highly specific enzyme
  • METTL21A is involved in Lys586 (Lys585) trimethylation of HSPA5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal carcinoma higher than those in normal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS